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Herein, we introduce a new class of metal\u2010free, organosilicon\u2010based\n                    <jats:sup>1<\/jats:sup>\n                    H MRI hotspot tracers that are directly compatible with conventional experimental and clinical MRI systems. These tracers exploit the distinct chemical shift of silicon\u2010shielded hydrogens (\u223c0\u00a0ppm) spectrally resolved from the biological\n                    <jats:sup>1<\/jats:sup>\n                    H background. Through architectural screening, we identified an optimized block copolymer micelle, denoted as Silicone\u2010Generated Hotspot Tracer (SiGHT), comprising polydimethylsiloxane (PDMS) core and a hydrophilic shell. SiGHT exhibits excellent chemical and colloidal stability and enables sensitive, background\u2010free\n                    <jats:sup>1<\/jats:sup>\n                    H chemical shift imaging at low concentrations (&lt; 0.5\u00a0mg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), while being non\u2010cytotoxic and well tolerated in vivo. The diagnostic potential of the developed probe has been demonstrated by successful\n                    <jats:sup>1<\/jats:sup>\n                    H MR hotspot visualization of tracer accumulation in 4T1 mouse tumors following intravenous administration. Importantly, we demonstrate robust tracer detection on both preclinical 7T and clinical 3T MRI scanners using standard\n                    <jats:sup>1<\/jats:sup>\n                    H MR sequences and commercial coils, underscoring its translational potential. Together, these results establish organosilicon micelles as clinically relevant, metal\u2010free\n                    <jats:sup>1<\/jats:sup>\n                    H MR hotspot tracers, opening an unexplored pathway to accessible, high\u2010sensitivity molecular imaging on existing MRI infrastructure.\n                  <\/jats:p>","DOI":"10.1002\/advs.77010","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:20:45Z","timestamp":1786008045000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bypassing Heteronuclear MRI: Metal\u2010Free Organosilicon Nanotracers for Background\u2010Free Hotspot\n                    <sup>1<\/sup>\n                    H Imaging on Clinical Hardware"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1145-6137","authenticated-orcid":false,"given":"Martin","family":"Orsagh","sequence":"first","affiliation":[{"name":"Department of Physical and Macromolecular Chemistry Faculty of Science Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-2181","authenticated-orcid":false,"given":"Dominik","family":"Havlicek","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Institute for Clinical and Experimental Medicine  Prague Czech Republic"},{"name":"Institute of Biophysics and Informatics First Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0902-2033","authenticated-orcid":false,"given":"Andrea","family":"Galisova","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Institute for Clinical and Experimental Medicine  Prague Czech Republic"},{"name":"BIOCEV First Faculty of Medicine Charles University  Vestec Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5731-2687","authenticated-orcid":false,"given":"Ondrej","family":"Sedlacek","sequence":"additional","affiliation":[{"name":"Department of Physical and Macromolecular Chemistry Faculty of Science Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6834-3462","authenticated-orcid":false,"given":"Daniel","family":"Jirak","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Institute for Clinical and Experimental Medicine  Prague Czech Republic"},{"name":"Institute of Biophysics and Informatics First Faculty of Medicine Charles University  Prague Czech Republic"},{"name":"Faculty of Health Studies Technical University of Liberec  Liberec Czech 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