{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:47:57Z","timestamp":1785937677717,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504702"],"award-info":[{"award-number":["82504702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia. Cordycepin, a natural adenosine analogue from traditional Chinese medicine\n                    <jats:italic>Cordyceps militaris<\/jats:italic>\n                    , possesses broad anti\u2011inflammatory and immunomodulatory properties, but its poor metabolic stability limits clinical use. Herein, 22 cordycepin derivatives for anti\u2010psoriasis were designed and synthesized. Among\u00a0them,\n                    <jats:bold>CPD3a<\/jats:bold>\n                    , featuring a stable C\u2500C glycosidic bond, exhibited potent anti\u2011inflammatory activity, high metabolic stability, and high resistance to in vivo metabolic deamination.\n                    <jats:bold>CPD3a<\/jats:bold>\n                    was formulated into a microneedle array (\n                    <jats:bold>CPD3a<\/jats:bold>\n                    \u2010MN) for the topical treatment of psoriasis. In a psoriasis\u2010like mouse model,\n                    <jats:bold>CPD3a<\/jats:bold>\n                    \u2010MN exhibited potent, dose\u2010dependent efficacy, significantly reducing pathological symptoms, ameliorating epidermal hyperplasia, and suppressing systemic inflammation. Meanwhile,\n                    <jats:bold>CPD3a<\/jats:bold>\n                    \u2010MN rebalanced systemic immunity by suppressing splenic neutrophils and inflammatory dendritic cells while increasing regulatory T cells and M2 macrophages. Activation of adenosine monophosphate\u2010activated protein kinase (AMPK)\/nuclear factor erythroid 2\u2010related factor 2 (NRF2) pathway and a marked antioxidant effect were also observed following\n                    <jats:bold>CPD3a<\/jats:bold>\n                    \u2010MN treatment. Transcriptomic analysis demonstrated that\n                    <jats:bold>CPD3a<\/jats:bold>\n                    \u2010MN modulated the psoriatic transcriptome, suppressing interleukin\u201017 (IL\u201017)\/nuclear factor\u2010kappa B (NF\u2010\u03baB)\u2010driven inflammatory networks and concurrently activating genes involved in keratinocyte differentiation and epidermal barrier restoration. Moreover,\n                    <jats:bold>CPD3a<\/jats:bold>\n                    \u2010MN was well\u2011tolerated, with good biocompatibility. Collectively,\n                    <jats:bold>CPD3a<\/jats:bold>\n                    represents a superior therapeutic alternative to cordycepin for topical psoriasis treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.77012","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:15:59Z","timestamp":1785935759000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A C\u2010Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti\u2010Psoriatic Activity via Microneedle Delivery"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7199-5024","authenticated-orcid":false,"given":"Wenfang","family":"Pan","sequence":"first","affiliation":[{"name":"Lingang Laboratory  Shanghai China"},{"name":"School of Physical Science and Technology ShanghaiTech University  Shanghai 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