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While biomolecules such as enzymes and DNA have been harnessed for biocomputation, implementing complex logic operations remains challenging due to signal attenuation, crosstalk, and instability inherent in molecular cascades. To overcome these limitations, we present a non\u2010cascaded biocomputing architecture based on spatially encoded, gradient\u2010responsive protocell communities embedded in a three\u2010dimensional hydrogel matrix. By leveraging differential reaction\u2013diffusion dynamics of input signals, distinct output regions are established across the spatial domain, enabling parallel, multi\u2010threshold computation without signal routing. This architecture achieves continuous spatial encoding and allows simultaneous readout of all output regions, supporting nonlinear logic operations with high fault tolerance. Using this framework, we demonstrate the successful implementation of both half\u2010adder and full\u2010adder logic operations via two\u2010input\/two\u2010output and three\u2010input\/two\u2010output configurations, respectively. Our approach provides a scalable, programmable platform for parallel biocomputation, offering a promising route toward low\u2010complexity, robust, and non\u2010cascaded molecular computing systems that bridge synthetic biology and computational science.<\/jats:p>","DOI":"10.1002\/advs.77019","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:04:09Z","timestamp":1787051049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatially Encoded Protocell Network for Non\u2010Cascaded Parallel Biocomputation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4019-7450","authenticated-orcid":false,"given":"Shuqi","family":"Wu","sequence":"first","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument, Key Laboratory of Biomedical Engineering of Ministry of Education, College of Biomedical Engineering 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