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Herein, we developed gallium\u2013quercetin nanoparticles (GQNPs) as an intranasally deliverable nanoplatform for multi\u2010target ferroptosis inhibition. In vitro, GQNPs suppressed ferroptosis by coordinating iron regulation and antioxidation. Ga\n                    <jats:sup>3<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    interfered with transferrin\u2010mediated iron uptake to restrict iron influx, while quercetin reduced oxidative stress and supported iron homeostasis, thereby decreasing ROS accumulation and improving mitochondrial function. In vivo, intranasal delivery of GQNPs effectively bypassed the blood\u2010brain barrier to recover motor coordination and cognitive function in PD mice. By integrating iron regulation, antioxidant activity, and mitochondrial protection within a single nanoplatform, this work highlights gallium\u2010based coordination nanoparticles as a promising therapeutic strategy for ferroptosis\u2010associated neurodegenerative diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.77025","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T11:43:48Z","timestamp":1786103028000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intranasal Delivery of Gallium\u2013Quercetin Nanoparticles for Multi\u2010Target Ferroptosis Inhibition in Parkinson's Disease"],"prefix":"10.1002","author":[{"given":"Keyang","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Radiology The First Affiliated Hospital of Soochow University School of Radiation Medicine and Protection Soochow University Suzhou 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