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Here, we present a biomimetic liquid metal (LM)\u2010based photothermal immunotherapeutic nanoplatform exploiting gallium\u2010based LMs to orchestrate cascade amplification of antitumor immunity. The engineered nanoplatform (B\u2013LM\u2013DMX\u2013\u03b1CD25) integrates an LM photothermal core with dual immunomodulatory components\u2014anti\u2010CD25 antibody for Treg depletion and stimulator of interferon genes (STING)\u00a0agonist 5,6\u2010dimethylxanthenone\u20104\u2010acetic acid (DMX) for innate immune activation\u2014while blood\u2010derived camouflaging enhances immune evasion and tumor accumulation. Quantitative RT\u2010PCR of 13 immune\u2010related genes confirmed STING engagement, robust CD8+ cytotoxic T\u2010cell infiltration, and Treg depletion in treated tumors. This platform operates through three synchronized mechanisms: (1) selective intratumoral Treg depletion dismantling immunosuppression; (2) near\u2010infrared\u2010triggered LM\u2010mediated photothermal therapy (58\u00b0C within 5\u00a0min) inducing immunogenic cell death and releasing tumor\u2010associated antigens; and (3) STING pathway activation promoting dendritic cell maturation and tumor\u2010specific cytotoxic T\u2010cell responses, collectively transforming immunologically \u201ccold\u201d TNBC into immune\u2010responsive tumors. In orthotopic 4T1 models, the nanoplatform achieves significant tumor regression with enhanced survival, while in metastatic models, it reduces pulmonary metastatic nodules and extends median survival beyond 70 days. This work establishes a paradigm\u2010shifting biomimetic LM\u2010based nanodelivery strategy addressing fundamental immunological barriers in TNBC through coordinated photothermal\u2013immunotherapy, offering a clinically translatable approach for TNBC.<\/jats:p>","DOI":"10.1002\/advs.77069","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:37:55Z","timestamp":1786462675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Blood Cell\u2010Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING\u2010Amplified Photothermal Immunity for Metastatic Triple\u2010Negative Breast Cancer Therapy"],"prefix":"10.1002","author":[{"given":"Nina","family":"Sang","sequence":"first","affiliation":[{"name":"Graduate School of Advanced Science and Technology Japan Advanced Institute of Science and Technology  1\u20101 Asahidai Nomi Ishikawa Japan"},{"name":"Institute of Multidisciplinary Research for Advanced Materials Tohoku University, 2\u20101\u20101 Katahira, Aoba\u2010ku  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1157-6174","authenticated-orcid":false,"given":"Eijiro","family":"Miyako","sequence":"additional","affiliation":[{"name":"Graduate School of Advanced Science and Technology Japan Advanced Institute of Science and Technology  1\u20101 Asahidai Nomi Ishikawa Japan"},{"name":"Institute of Multidisciplinary Research for Advanced Materials Tohoku University, 2\u20101\u20101 Katahira, Aoba\u2010ku  Sendai Miyagi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010020\u201006030\u20105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9041010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41523\u2010022\u201000468\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201006\u20103045"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.379"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v12.i3.164"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.7554"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.8931"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy517"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy518"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"v859","DOI":"10.1093\/annonc\/mdz394.010","article-title":"KEYNOTE\u2010119: Phase III Study of pembrolizumab (pembro) Versus Single\u2010Agent Chemotherapy (chemo) for Metastatic Triple Negative Breast Cancer (mTNBC)","volume":"30","author":"Cort\u00e9s J.","year":"2019","journal-title":"Annals of Oncology"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(17)30904\u2010X"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201014\u20100432"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2019.04.004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/341654","article-title":"FOXP3 transcription Factor: A Candidate Marker for Susceptibility and Prognosis in Triple Negative Breast Cancer","volume":"2014","author":"Fiori Lopes L.","year":"2014","journal-title":"BioMed Research International"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09707"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.9584"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201602225"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b07249"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201705710"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf252"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011730\u20108"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42114\u2010025\u201001434\u20107"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b05749"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3380"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","article-title":"Oncology Meets Immunology: The Cancer\u2010Immunity Cycle","volume":"39","author":"Chen D. 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