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To date, artificial scaffolds have been developed from inert materials to bioactive materials and demonstrate the capabilities to promote bone repair. However, the complex physiological changes that occur during bone repair pose significant challenges to their practical clinical applications. In this Review, we summarize the studies of bone biology and the evolution of materials design in the context of bone\u2010tissue engineering applications. Specifically, we emphasize the role of biomaterials from a materials science perspective in regulating cell fates. Furthermore, we introduce the concept of programmable bio\u2010interactive materials as a potential solution for bone regeneration. These materials possess the ability to dynamically and precisely interact with biological systems, guiding the bone\u2010tissue regeneration process. Additionally, we discuss the unmet needs and current challenges faced in the development of bio\u2010interactive materials for bone\u2010tissue regeneration. By highlighting emerging strategies in the field, we aim to shed light on future directions for research and development in this exciting area of study.<\/jats:p>","DOI":"10.1002\/advs.77087","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T16:43:15Z","timestamp":1788108195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio\u2010Interactive Materials"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-8039","authenticated-orcid":false,"given":"Qingrui","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing People's Republic of China"},{"name":"Interdisciplinary Research Center For Advanced Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuming","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing People's Republic of China"},{"name":"National Clinical Research Center for Orthopedics Sports Medicine &amp; Rehabilitation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiang","family":"Mao","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center For Advanced Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5391-4477","authenticated-orcid":false,"given":"Pengbin","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing People's Republic of China"},{"name":"National Clinical Research Center for Orthopedics Sports Medicine &amp; Rehabilitation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6782-1749","authenticated-orcid":false,"given":"Licheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing People's Republic of China"},{"name":"National Clinical Research Center for Orthopedics Sports Medicine &amp; Rehabilitation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-9922","authenticated-orcid":false,"given":"Jianjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Center For Advanced Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4279-1704","authenticated-orcid":false,"given":"Peifu","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Chinese PLA General Hospital  Beijing People's Republic of China"},{"name":"National Clinical Research Center for Orthopedics Sports Medicine &amp; Rehabilitation  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,30]]},"reference":[{"key":"e_1_2_24_2_1","doi-asserted-by":"publisher","DOI":"10.4102\/phcfm.v11i1.1908"},{"key":"e_1_2_24_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0244291"},{"key":"e_1_2_24_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.09.028"},{"key":"e_1_2_24_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010020\u20100204\u20102"},{"key":"e_1_2_24_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202100408"},{"key":"e_1_2_24_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010019\u20100150\u2010z"},{"key":"e_1_2_24_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010021\u201000289\u20108"},{"key":"e_1_2_24_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav7756"},{"key":"e_1_2_24_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2666\u20107568(21)00172\u20100"},{"key":"e_1_2_24_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004890"},{"key":"e_1_2_24_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12887\u2010022\u201003199\u20100"},{"key":"e_1_2_24_13_1","doi-asserted-by":"publisher","DOI":"10.34133\/bmef.0004"},{"key":"e_1_2_24_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)03507\u20108"},{"key":"e_1_2_24_15_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1533\/9781845696610.2.154","volume-title":"Bone Repair Biomaterials","author":"Gonz\u00c1Lez\u2010Carrasco J. 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