{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:24:32Z","timestamp":1786973072424,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560488"],"award-info":[{"award-number":["82560488"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160129"],"award-info":[{"award-number":["82160129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473266"],"award-info":[{"award-number":["82473266"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer. F7 was highly expressed in tumor tissues and closely associated with lymph node metastasis, poor prognosis, and reduced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell infiltration. Tumor\u2010derived autocrine F7 interacted with ITGA2 on the cancer cell surface and activated ITGA2\u2010associated FAK\u2013NF\u2010\u03baB signaling and promoted invasion, migration, and anoikis resistance. F7 induced PD\u2010L1 expression in a manner partly dependent on ITGA2\u2010mediated PI3K\u2013AKT signaling and promoted collagen I deposition in liver metastatic lesions, which was associated with reduced CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell infiltration. Co\u2010immunoprecipitation showed that the K1.2 and K1.3 regions of F7 mediated its interaction with the N\u2010terminal extracellular region of ITGA2. Further investigations identified HNF4A as an upstream transcription factor of F7, with anoikis\u2010associated stress enhancing HNF4A nuclear accumulation and F7 transcription. Notably, ThonningianinA (THA) was identified as a potential F7\u2010targeting small molecule that suppressed F7\u2010associated malignant phenotypes, reduced tumor growth, and enhanced the antitumor efficacy of anti\u2013PD\u20101 therapy. These findings support F7 as a potential therapeutic target for metastatic gastric cancer.\n                  <\/jats:p>","DOI":"10.1002\/advs.77095","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:27:04Z","timestamp":1786969624000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-3095","authenticated-orcid":false,"given":"Lei","family":"Gao","sequence":"first","affiliation":[{"name":"The Second Hospital &amp; Clinical Medical School Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinying","family":"Han","sequence":"additional","affiliation":[{"name":"The Second Hospital &amp; Clinical Medical School Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Hospital &amp; Clinical Medical School Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuemei","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Hospital &amp; Clinical Medical School Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bofang","family":"Wang","sequence":"additional","affiliation":[{"name":"Cancer Center, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baohong","family":"Gu","sequence":"additional","affiliation":[{"name":"Cancer Center, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Hospital &amp; Clinical Medical School Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xiang","sequence":"additional","affiliation":[{"name":"The Second Hospital &amp; Clinical Medical School Lanzhou University  Lanzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, the First Medical Centre Chinese PLA General Hospital  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0018-480X","authenticated-orcid":false,"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Hospital &amp; Clinical Medical School Lanzhou University  Lanzhou People's Republic of China"},{"name":"Cancer Center, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"635","article-title":"The Lancet","volume":"396","author":"Smyth E. 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