{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:26:52Z","timestamp":1786969612378,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570574"],"award-info":[{"award-number":["82570574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20250484813"],"award-info":[{"award-number":["20250484813"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Environmental nanoplastic exposure is linked to metabolic disorders, yet its impact on pancreatic immune\u2010endocrine homeostasis and \u03b2\u2010cell identity regulation remains poorly defined. Rats were exposed to polystyrene nanoplastics(PS\u2010NPs) for 12 weeks under a control or high\u2010fat diet. Pancreatic injury and phenotypes were assessed biochemically, histologically, and ultrastructurally; single\u2010nucleus RNA\u2010seq delineated cell\u2010specific transcription and intercellular networks. Mechanistic validation used cell co\u2010cultures with MHC\u2010I modulation, and translational relevance was assessed in a human exposure cohort. Chronic PS\u2010NPs exposure exacerbated hyperglycemia and glucose intolerance, and induced pancreatic damage. Single\u2010nucleus transcriptomics identified \u03b2 cells and dendritic cells (DCs) as the most responsive populations. PS\u2010NPs drove \u03b2\u2010cell dedifferentiation, characterized by downregulation of key identity markers (Mafa, Pdx1, Nkx6.1). Concurrently, DCs exhibited a maturation\u2010like phenotype with robust upregulation of MHC\u2010I and inflammatory pathways. Ligand\u2010receptor analysis revealed enhanced proinflammatory crosstalk between DCs and \u03b2 cells. Functionally, MHC\u2010I upregulation in DCs activated TLR4\/NF\u2010\u03baB signaling and drove \u03b2\u2010cell dedifferentiation in vitro. Consistently, occupationally exposed individuals showed elevated circulating HLA\u2010A levels and metabolic abnormalities. These findings identify an MHC\u2010I\u2010dependent DCs\u2010\u03b2\u2010cell inflammatory axis through which PS\u2010NPs disrupt pancreatic immune\u2010endocrine homeostasis and promote \u03b2\u2010cell dedifferentiation, revealing mechanisms underlying PS\u2010NPs\u2010induced metabolic dysfunction.<\/jats:p>","DOI":"10.1002\/advs.77096","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:51:11Z","timestamp":1786967471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polystyrene Nanoplastics Drive \u03b2\u2010Cell Dedifferentiation Through Dendritic Cell\u2010Intrinsic MHC\u2010I\u2010Dependent Inflammatory Crosstalk"],"prefix":"10.1002","author":[{"given":"Conghui","family":"Qiao","sequence":"first","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Health Ministry of Education Department of Nutrition and Food Hygiene the National Key Discipline School of Public Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Health Ministry of Education Department of Nutrition and Food Hygiene the National Key Discipline School of Public Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Health Ministry of Education Department of Nutrition and Food Hygiene the National Key Discipline School of Public Health Harbin Medical University  Harbin People's Republic of 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of Education Department of Nutrition and Food Hygiene the National Key Discipline School of Public Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6094-9651","authenticated-orcid":false,"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Precision Nutrition and Health Ministry of Education Department of Nutrition and Food Hygiene the National Key Discipline School of Public Health Harbin Medical University  Harbin People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6199-6540","authenticated-orcid":false,"given":"Xinyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Toxicology College of Public Health Harbin Medical University  Harbin Heilongjiang People's Republic of 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