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Using single\u2010cell RNA sequencing of human scalp follicles from balding and non\u2010balding regions, we constructed a high\u2010resolution molecular anatomy atlas of the hair follicle and its microenvironment. We identified significant silencing of Wingless\u2010related integration site 5A (WNT5A) signaling, which was widely known as the trigger of non\u2010canonical WNT signaling pathway, in hair follicle stem cells (HFSCs) from balding areas, leading to downregulation of the transcription factor ATF3 and its target FOSB. Therapeutically, functional validation showed that activating the WNT5A\u2010ATF3\u2010FOSB axis maintained HFSC competence in AGA murine models and significantly inhibited the progression of AGA. Our findings reveal a critical molecular axis in AGA pathogenesis, highlighting its potential as a therapeutic target for hair loss disorders.<\/jats:p>","DOI":"10.1002\/advs.77109","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:51:00Z","timestamp":1786549860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010Cell Profiling Reveals a Protective WNT5A\u2010ATF3\u2010FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9949-2841","authenticated-orcid":false,"given":"Ruiyu","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Shanghai East Hospital School of Medicine Tongji University Shanghai 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