{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:47:29Z","timestamp":1786549649450,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32372322"],"award-info":[{"award-number":["32372322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82503553"],"award-info":[{"award-number":["82503553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224ACB215009"],"award-info":[{"award-number":["20224ACB215009"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20232ACB205024"],"award-info":[{"award-number":["20232ACB205024"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20242BAB21029"],"award-info":[{"award-number":["20242BAB21029"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immunogenic cell death (ICD)\u2010based whole\u2010cell personalized cancer immunotherapies present full tumor antigens but suffer from poor immunogenicity, early clearance, and a glutathione (GSH)\u2010rich immunosuppressive tumor microenvironment (TME). Here, we report a TME\u2010responsive immunotherapeutic platform, DTBEI@CS@MnO\n                    <jats:sub>2<\/jats:sub>\n                    , which integrates immunogenicity\u2010enhanced dead tumor cell bodies (DTBEI) with Mn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \u2010potentiated innate immunity. Tumor cells preloaded with indocyanine green (ICG) are sequentially functionalized with a chitosan (CS) interlayer followed by MnO\n                    <jats:sub>2<\/jats:sub>\n                    adsorption (CS@MnO\n                    <jats:sub>2<\/jats:sub>\n                    ) via electrostatic interactions. Upon near\u2010infrared laser irradiation, ICG\u2010mediated photodynamic\/photothermal effect induces potent ICD, generating DTBEI. Within the acidic and GSH\u2010enriched TME, the CS@MnO\n                    <jats:sub>2<\/jats:sub>\n                    coating disassembles to release DTBEI and MnO\n                    <jats:sub>2<\/jats:sub>\n                    . DTBEI provides endogenous antigens and ICD\u2010associated danger signals, while MnO\n                    <jats:sub>2<\/jats:sub>\n                    is reduced by GSH to Mn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    . The resulting Mn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    amplifies DTBEI\u2010 and tumor\u2010derived deoxyribonucleic acid\u2010triggered cyclic GMP\u2010AMP synthase (cGAS)\u2010stimulator of interferon genes (STING) activation and downstream immune\u2010stimulatory effects, thereby synergistically promoting dendritic cell maturation, antigen cross\u2010presentation, and tumor\u2010specific T\u2010cell priming. Consequently, DTBEI@CS@MnO\n                    <jats:sub>2<\/jats:sub>\n                    elicits durable anti\u2010tumor immunity, effectively inhibiting tumor growth and suppressing recurrence and metastasis, while establishing T\u2010cell memory responses. Importantly, this strategy shows broad applicability in multiple tumor models, including CT26 colon cancer, 4T1 breast cancer, and B16F10 melanoma, while maintaining favorable biocompatibility. Overall, these findings highlight a materials\u2010based approach for personalized cancer immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.77126","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:53:11Z","timestamp":1786546391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Versatile Co\u2010Engineering of Immunogenic Cell Death\u2010Primed Dead Tumor Cell Bodies With Tumor\u2010Activated MnO\n                    <sub>2<\/sub>\n                    for cGAS\u2010STING\u2010Potentiated Personalized Immunotherapy"],"prefix":"10.1002","author":[{"given":"Bolun","family":"Xu","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanchang University  Nanchang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8258-5535","authenticated-orcid":false,"given":"Xuan","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Nanchang University  Nanchang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuquan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Nanchang University  Nanchang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihua","family":"Ji","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources Nanchang University  Nanchang P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-2359","authenticated-orcid":false,"given":"Hao","family":"Wan","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Nanchang University  Nanchang P. R. China"},{"name":"State Key Laboratory of Food Science and Resources Nanchang University  Nanchang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar7112"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.85"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201016\u20100146"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300121"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.59717\/j.xinn\u2010mater.2023.100018"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2025.09.007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2024.03.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207475"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2020.02.007"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.149446"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011269\u20108"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202303328"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202314501"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202420325"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118464"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.121839"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010024\u201002163\u2010z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc4373"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202409250"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.144910"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.150364"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c15139"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.01.029"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025452\u20103"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40580\u2010021\u201000286\u20103"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.173836"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2025.102958"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202310300"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00054"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.054"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114288"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.3191"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202505179"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77126","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.77126","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77126","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:53:12Z","timestamp":1786546392000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":33,"alternative-id":["10.1002\/advs.77126"],"URL":"https:\/\/doi.org\/10.1002\/advs.77126","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"2026-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e77126"}}