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Conventional passive dressings lack the capacity to actively modulate this complex microenvironment. Here, we report a wireless, dual\u2010responsive hydrogel (PVA\/P(VDF\u2010TrFE)\/BiOClBr@PDA, PPBP) based on porous poly(vinyl alcohol) (PVA), piezoelectric poly(vinylidene fluoride\u2010trifluoroethylene) (P(VDF\u2010TrFE)), and polydopamine\u2010modified bismuth oxybromide chloride (BiOClBr@PDA). The constructed hydrogel orchestrates piezoelectric stimulation and piezo\u2010photocatalysis to simultaneously eradicate infection and accelerate tissue regeneration. Under concurrent ultrasonic and optical stimulation, this platform efficiently transduces mechanical and light energy into therapeutic electrical cues and reactive oxygen species (ROS). This dual\u2010mode activation enables enhanced antibacterial efficacy against diverse bacterial strains, significantly outperforming single\u2010mode treatments while maintaining favorable biocompatibility. In an infected wound model, the constructed composite hydrogel PPBP effectively inhibits bacteria and attenuates inflammatory responses via controlled ROS generation, while piezoelectric stimulation supports re\u2010epithelialization and collagen deposition. Together, these effects promote accelerated and structurally improved wound healing. This work establishes a paradigm for utilizing multi\u2010source energy\u2010responsive hydrogels as an active strategy for regulating infected wound environments and supporting functional skin regeneration.<\/jats:p>","DOI":"10.1002\/advs.77132","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:17:28Z","timestamp":1786969048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dual\u2010Responsive Hydrogels Integrate Bioelectrical Stimulation and Piezo\u2010Photocatalysis for Regenerative Treatment of Infected Wounds"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1573-0279","authenticated-orcid":false,"given":"Baoying","family":"Dai","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM) Jiangsu Provincial Industrial Technology Engineering Center for Flexible 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