{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:43:21Z","timestamp":1791362601210,"version":"4.3.1"},"reference-count":71,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2026\u2010RISE\u201011\u2010014\u201003"],"award-info":[{"award-number":["2026\u2010RISE\u201011\u2010014\u201003"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201002273102"],"award-info":[{"award-number":["RS\u20102025\u201002273102"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Systemic pharmacokinetics critically govern nanomedicine delivery, yet conventional in vitro models fail to capture the dynamic interplay between circulation, clearance, and tumor transport. This limitation hinders accurate prediction of therapeutic performance. A microfluidic tumor platform is developed to recapitulate in vivo pharmacokinetic behavior and size\u2010dependent nanoparticle delivery within a controlled experimental system. The platform integrates time\u2010resolved concentration control, a membrane\u2010based vascular barrier, and 3D tumor spheroids to emulate systemic exposure and tumor microenvironment simultaneously. Using paclitaxel\u2010loaded polymeric micelles in a non\u2010small cell lung cancer model, the platform reproduces in vivo\u2013like concentration\u2013time profiles and recapitulates formulation\u2010dependent therapeutic responses. Notably, both intratumoral accumulation and antitumor efficacy are shown to depend on pharmacokinetic exposure and nanoparticle size, consistent with in vivo observations. The system further captures size\u2010dependent delivery patterns associated with enhanced permeability and retention. By linking systemic pharmacokinetics with tumor\u2010level transport and response, this platform establishes a predictive framework for evaluating nanomedicine performance beyond conventional static assays.<\/jats:p>","DOI":"10.1002\/advs.77137","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:21:41Z","timestamp":1786699301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recapitulating In Vivo Pharmacokinetics and Size\u2010Dependent Nanomedicine Delivery in a Microfluidic Platform"],"prefix":"10.1002","author":[{"given":"Su Jeong","family":"Kang","sequence":"first","affiliation":[{"name":"College of Pharmacy Chungbuk National University  Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Sup","family":"Yoon","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chungbuk National University  Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Min","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chungbuk National University  Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jeong","family":"Jo","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chungbuk National University  Cheongju Republic of Korea"},{"name":"Department of Pharmaceutical Chemistry University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae Eun","family":"Jin","sequence":"additional","affiliation":[{"name":"Pharmacology and Narcotics Research Division National Institute of Food and Drug Safety Evaluation (NIFDS) Ministry of Food and Drug Safety (MFDS)  Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6023-9930","authenticated-orcid":false,"given":"Dae Hwan","family":"Shin","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chungbuk National University  Cheongju Republic of Korea"},{"name":"Chungbuk National University Hospital  Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.122.001060"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma12182945"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.12.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.05.05.079285"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824\u2010023\u201000441\u20103"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay7513"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.952726","article-title":"A Comparative Study of Tumour\u2010on\u2010Chip Models With Patient\u2010Derived Xenografts for Predicting Chemotherapy Efficacy in Colorectal Cancer Patients","volume":"10","author":"Ong L. J. Y.","year":"2022","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.26845"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi9119"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14132601"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001552\u20100"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.03.053"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010024\u201001884\u20104"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119547"},{"issue":"1","key":"e_1_2_11_16_1","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s42003-021-02526-y","article-title":"Tumour\u2010on\u2010Chip Microfluidic Platform for Assessment of Drug Pharmacokinetics and Treatment Response","volume":"4","author":"Petreus T.","year":"2021","journal-title":"Communications Biology"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202401821"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248\u2010020\u20100430\u2010y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010025\u201002410\u2010w"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201009815\u20109"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10020057"},{"issue":"1","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41378-021-00277-8","article-title":"Tumor\u2010on\u2010a\u2010Chip: From Bioinspired Design to Biomedical Application","volume":"7","author":"Liu X.","year":"2021","journal-title":"Microsystems & Nanoengineering"},{"key":"e_1_2_11_23_1","unstructured":"E. Commission Report on the statistics on the use of animals for scientific purposes in the Member States of the European Union in 2015\u20132017 COM(2020) 16 final; European Commission: Brussels Belgium 2020."},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14503"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576\u2010022\u201000466\u20109"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI175824"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010018\u20100034\u20107"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.52783\/jns.v14.1518"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3lc00531c"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13036\u2010023\u201000372\u20106"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7LC01248A"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.06.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.s150196"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022814"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3001624"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0LC00419G"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.900481"},{"key":"e_1_2_11_38_1","unstructured":"U.S. Food and Drug Administration O. C. o. E. Project Optimus: Framework for Oncology Dose Optimization. (U.S. Food and Drug Administration Silver Spring MD 2022) Available online:https:\/\/www.fda.gov\/about\u2010fda\/oncology\u2010center\u2010excellence\/project\u2010optimus(accessed August 11 2026).."},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538\u20107445.Am2024\u20104183"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00212"},{"key":"e_1_2_11_41_1","article-title":"Repetitive Blood Sampling from the Subclavian Vein of Conscious Rat","volume":"180","author":"Wang L.","year":"2022","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1718245"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2025.111460"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202500240"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw1317"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122482"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4LC01011F"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10020270"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4LC00990H"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2023.115271"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202402311"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0LC00424C"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14040935"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26031028"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2019.02.070"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/app15063189"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.08.027"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201000750\u20103"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9LC00550A"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4LC01043D"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300692"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010190"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184466"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1452298"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517\u2010024\u201003062\u20107"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.07.010"},{"key":"e_1_2_11_67_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.addr.2015.09.012","article-title":"PEGylation as a Strategy for Improving Nanoparticle\u2010Based Drug and Gene Delivery","volume":"99","author":"Suk J. S.","year":"2016","journal-title":"Advanced drug delivery reviews"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.15226\/2374\u20106866\/2\/1\/00122"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio\u20102021\u20100247"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13030373"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100181"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2026.115029"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.77137","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:21:44Z","timestamp":1786699304000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":71,"alternative-id":["10.1002\/advs.77137"],"URL":"https:\/\/doi.org\/10.1002\/advs.77137","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"2026-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e77137"}}