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Conventional strategies for regulating transport in polymer networks primarily focus on tuning molecular diffusion through network mesh size and polymer chemistry, whereas convection is often considered negligible because nanoscale\u2010mesh networks typically exhibit low fluid permeability. Although hydraulic pressure is a well\u2010established driving force for convection in porous media, extending pressure\u2010driven convection to non\u2010porous polymer networks has remained fundamentally challenging because they can undergo substantial deformation or fracture under pressure gradients. Here, we demonstrate that hydraulic pressure applied across mechanically tough and grid\u2010supported hydrogels enables robust and tunable solute transport while maintaining structural integrity. The characteristic transport time can be experimentally modulated by up to 65\u2010fold, consistent with a coupled diffusion\u2013convection model. Beyond tuning transport kinetics, applied pressure enhances size\u2010 and charge\u2010dependent transport selectivity by up to 5.4\u2010fold compared to pressure\u2010free conditions. As a proof of concept, we demonstrate pressure\u2010programmed antimicrobial delivery that dynamically controls doxorubicin transport while blocking bacterial penetration. These findings identify pressure\u2010regulated convection as an underexplored mechanism for controlling transport in polymer networks.<\/jats:p>","DOI":"10.1002\/advs.77159","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:50:31Z","timestamp":1787219431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hydraulic Pressure\u2010Programmed Molecular Transport in Tough Hydrogels"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4773-4194","authenticated-orcid":false,"given":"Yijie","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahd","family":"Alnasser","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6421-0937","authenticated-orcid":false,"given":"Akhiri","family":"Zannat","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-629X","authenticated-orcid":false,"given":"Zhenda","family":"He","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6652-2358","authenticated-orcid":false,"given":"Jiayi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Sibley School of Mechanical and Aerospace Engineering Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sibley School of Mechanical and Aerospace Engineering Cornell University  Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungmin","family":"Hong","sequence":"additional","affiliation":[{"name":"U.S. Army Corps of Engineers Engineer Research and Development Center Construction Engineering Research Laboratory  Champaign Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1187-493X","authenticated-orcid":false,"given":"Xinyue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Materials Science Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01177"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00396"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.newton.2025.100168"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.3.703"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/hearts7020017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10404\u2010021\u201002480\u20105"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.1424298"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511805134","volume-title":"Diffusion: Mass transfer in fluid systems","author":"Cussler E. 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