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This study focuses on tephritids, particularly\n                    <jats:italic>Bactrocera dorsalis<\/jats:italic>\n                    , due to its global invasiveness and severe agricultural impact. We conducted comparative single\u2010nucleus transcriptomics of the antennal olfactory organ in\n                    <jats:italic>B. dorsalis<\/jats:italic>\n                    and\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    , revealing uneven transcriptomic divergence across cell types: structural cells showed higher cross\u2010species similarity, while sensory neuronal populations and receptor expression were more divergent. Notably, in\n                    <jats:italic>B. dorsalis<\/jats:italic>\n                    , ammonia detection involves an additional candidate neuronal population with\n                    <jats:italic>BdorAmt\/BdorOrco<\/jats:italic>\n                    transcript co\u2010detection, contrasting with\n                    <jats:italic>D. melanogaster<\/jats:italic>\n                    , where ammonia detection is mediated by\n                    <jats:italic>Amt<\/jats:italic>\n                    \u2010expressing neurons independently of\n                    <jats:italic>Orco<\/jats:italic>\n                    . This derived molecular sensing logic helps meet the ecological demands of\n                    <jats:italic>B. dorsalis<\/jats:italic>\n                    , in which females use ammonia as an important cue to locate bird droppings as a potential supplementary nutritional resource. Our results suggest that cell\u2010type\u2010dependent transcriptomic divergence may represent one important route through which insect olfactory systems adapt, with neuronal diversification contributing to molecular sensing pathways tailored to specific ecological demands.\n                  <\/jats:p>","DOI":"10.1002\/advs.77168","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:48:56Z","timestamp":1786967336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetric Evolution of Antennal Cell Types Underlies a Derived Ammonia\u2010Sensing Logic for Ecological Adaptation in\n                    <i>Bactrocera dorsalis<\/i>"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5852-2336","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, 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