{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T10:24:26Z","timestamp":1787221466621,"version":"build-2736575974"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302760"],"award-info":[{"award-number":["82302760"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472493"],"award-info":[{"award-number":["82472493"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared inflammatory pathologies, yet lack effective disease\u2010modifying therapies. Pro\u2010inflammatory macrophages are central to their pathogenesis, but their selective therapeutic modulation remains a major challenge. Here, we first used single\u2010cell transcriptomics to identify a conserved, pathogenic interleukin\u20101\u03b2 (IL\u20101\u03b2)\n                    <jats:sup>+<\/jats:sup>\n                    macrophage signature fueled by a shared nuclear factor\u2010\u03baB (NF\u2010\u03baB)\u2010inflammation axis in human OA and IVDD. We engineered a macrophage\u2010biomimetic nanosystem (GM1\u2010dMOF@PTL), a \u201cdoppelg\u00e4nger\u201d nanosystem designed for targeted cellular reprogramming. The platform consists of a Parthenolide (PTL)\u2010loaded, lysosome\u2010escaping metal\u2013organic framework (MOF) core camouflaged with inflammatory macrophage membranes, with the IL\u20101\u03b2 decoy receptor, interleukin\u20101 receptor type 2 (IL\u20101R2), overexpressed. This design enables a multi\u2010pronged immunomodulatory strategy: the decoy receptor could neutralize extracellular IL\u20101\u03b2, while the macrophage\u2010biomimetic surface facilitates homotypic targeting and preferential uptake by inflammatory macrophages. Upon internalization, the nanosystem potently suppresses the NF\u2010\u03baB\/ NLR family pyrin domain containing 3 (N\u00a0inflammasome axis, effectively disarming the cell's pyroptotic program. Crucially, local administration in mouse models preserved disc and cartilage integrity, resolved inflammation, and provided sustained alleviation of pain hypersensitivity. This study presents a unified, disease\u2010modifying nanotherapeutic strategy that targets a shared cellular driver by synergistically neutralizing inflammatory signals and reprogramming pathogenic immune cells to attenuate\u00a0both spine and joint degeneration.\n                  <\/jats:p>","DOI":"10.1002\/advs.77171","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:35:20Z","timestamp":1787218520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Decoy\u2010Receptor\u2010Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3407-0715","authenticated-orcid":false,"given":"Fudong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Spine Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2067-2061","authenticated-orcid":false,"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Spine Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3117-5009","authenticated-orcid":false,"given":"Zhiqiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Spine Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9659-1276","authenticated-orcid":false,"given":"Bing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Spine Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5836-8886","authenticated-orcid":false,"given":"Linhui","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Spine Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9062-4735","authenticated-orcid":false,"given":"Chen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Spine Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5880-9548","authenticated-orcid":false,"given":"Jialin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Naval Medical Center of PLA Navy Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-8383","authenticated-orcid":false,"given":"Kaiqiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Spine Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"},{"name":"Department of Orthopedics Naval Medical Center of PLA Navy Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8469-5797","authenticated-orcid":false,"given":"Tianyi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Spine Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-0108","authenticated-orcid":false,"given":"Jiangang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Spine Center Shanghai Changzheng Hospital Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"5","article-title":"Cell Reprogramming Strategies for Treating Osteoarthritis and Intervertebral Disc Degeneration","volume":"16","author":"Jiang Z.","year":"2024","journal-title":"Aging and 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