{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:24:39Z","timestamp":1787664279225,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Postoperative recurrence and metastasis are the primary causes of mortality in colorectal cancer (CRC). And its immunosuppressive tumor microenvironment (TME) often results in the poor response to immune checkpoint blockade (ICB). This study designed an injectable and adhesive tannic acid\u2010iron hydrogel for locally mild photothermal therapy (PTT, \u2264 45\u00b0C) and ferroptosis to prevent the postoperative recurrence and metastasis in combination with\u00a0programmed death ligand 1 (PD\u2010L1) checkpoint blockade immunotherapy. First, this system was assembled from tannic acid (TA) and gelatin microspheres to form an injectable and adhesive hydrogel (Gel\/TA). Subsequently, the metal\u2010polyphenol network (MPNs) was introduced via Fe\n                    <jats:sup>3+<\/jats:sup>\n                    \u2010TA interactions, providing photothermal conversion and Fe\n                    <jats:sup>3+<\/jats:sup>\n                    release capabilities (Gel\/TA\/Fe\n                    <jats:sup>3+<\/jats:sup>\n                    ). Gel\/TA\/Fe\n                    <jats:sup>3+<\/jats:sup>\n                    hydrogels not only ablated tumor cells and induced immunogenic cell death (ICD) under near\u2010infrared (NIR) irradiation, but also elicited ferroptosis of both tumor cells and tumor\u2010associated macrophage (TAMs), resulting in dendritic cells\u00a0(DCs) maturation, T\u2010cell infiltration and down\u2010regulation of ferroptosis\u2010sensitive M2\u2010type TAMs levels. Therefore, in cooperation with \u03b1PD\u2010L1, Gel\/TA\/Fe\n                    <jats:sup>3+<\/jats:sup>\n                    could not only evoke an immune response against the primary tumor, but also promote an abscopal effect against distant metastatic tumor. This work presented a novel material for CRC postoperative therapy via the synergistic effect of immediate tumor\u2010cell killing and enhanced immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/advs.77186","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:10:32Z","timestamp":1787663432000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron\u2010Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti\u2010Tumor Immunity in Colorectal Cancer"],"prefix":"10.1002","author":[{"given":"Yuan","family":"Zhu","sequence":"first","affiliation":[{"name":"Central Laboratory Putuo Hospital Shanghai University of Traditional Chinese Medicine  Shanghai 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Central School of Clinical Medicine Anhui Medical University  Shanghai China"},{"name":"Shanghai Putuo People's Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1780-2563","authenticated-orcid":false,"given":"Zeting","family":"Yuan","sequence":"additional","affiliation":[{"name":"Central Laboratory Putuo Hospital Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Shanghai Putuo Central School of Clinical Medicine Anhui Medical University  Shanghai 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