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Precise regulation of fibroblast\u2010to\u2010myofibroblast transformation and macrophage polarization is therefore essential yet challenging. Fibroblast activation protein (FAP) has been identified as a key bio\u2010cue in pulmonary and hepatic fibrosis, but whether FAP\u2010targeting peptide (FTP) within a biomimetic system can address this dilemma remains unclear. Here, a methacrylated hyaluronic acid hydrogel microneedle patch (CAF@MN) integrating a dual\u2010targeting biomimetic nanozyme system (Cu\u2010CeO\n                    <jats:sub>2<\/jats:sub>\n                    @ABs\u2010FTP) modified with apoptotic bodies (ABs) membranes and FTP is developed. Cu\u2010CeO\n                    <jats:sub>2<\/jats:sub>\n                    nanocomposites activate fibroblast functions and exhibit anti\u2010inflammatory, antibacterial, antioxidant, and pro\u2010angiogenic activities. The ABs membrane enables macrophage targeting and M2 polarization, while FTP specifically modulates myofibroblast activation. The microneedle architecture enhances deep local delivery and nanozyme utilization. In mouse and rabbit full\u2010phase wound models, the system achieves accelerated wound healing, reduced inflammation, and attenuated hypertrophic scars. Single\u2010cell RNA sequencing further elucidates the dual\u2010targeted regulatory mechanisms underlying anti\u2010inflammation and scar suppression.\n                  <\/jats:p>","DOI":"10.1002\/advs.77192","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:22:07Z","timestamp":1786969327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual\u2010Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti\u2010Inflammatory and Anti\u2010Fibrotic Effects"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9164-9072","authenticated-orcid":false,"given":"Hongyi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Ear Reconstruction Institute Shanghai East Hospital School of Medicine Tongji University Shanghai People's Republic of 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