{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:07:48Z","timestamp":1789546068533,"version":"build-2803163510"},"reference-count":401,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Climate change has intensified drought frequency and severity, threatening global food security, particularly for staple crops like maize, wheat, and soybean. As central secondary metabolites, flavonoids orchestrate cellular redox homeostasis, stress signal transduction, and metabolic plasticity during plant drought responses. Previous reviews are confined to isolated molecular cascades and separate treatment of flavonoid metabolism, rhizosphere microecology, and agronomic mitigation strategies, failing to establish an integrated multi\u2010scale regulatory framework. To fill this fragmented gap, this review integrates advances in plant physiology, microbial ecology, and nanobiotechnology to construct a cross\u2010scale framework of flavonoid\u2010mediated drought resistance in major food crops. We systematically summarize species\u2010specific flavonoid regulatory networks and metabolic reprogramming triggered by drought\u2010induced oxidative stress, dissect rhizosphere microbiome effects on flavonoid biosynthesis and drought signaling, and elaborate novel mechanisms whereby nanomaterials reshape flavonoid metabolism and boost drought tolerance via tuning ROS homeostasis. Furthermore, this work integrates soil amendment and precision irrigation to decipher synergistic drought\u2010resistance crosstalk among agronomic practices, crop metabolism, and root\u2010associated microbiota. Collectively, this review unifies molecular, microbial, technological, and agronomic perspectives to establish a multi\u2010scale, interdisciplinary framework for crop drought adaptation. It delivers fundamental theoretical support for climate\u2010resilient agriculture and outlines priority research avenues to safeguard global food security.<\/jats:p>","DOI":"10.1002\/advs.77194","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:50:32Z","timestamp":1789545032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5327-0432","authenticated-orcid":false,"given":"Xiaoyi","family":"Duan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Efficient Production of Forest Resources Beijing Forestry University  Beijing China"},{"name":"The College of Forestry Beijing Forestry University  Beijing China"},{"name":"Ecological Observation and Research Station of Heilongjiang Sanjiang Plain Wetlands 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