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Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed an electronic chip\u2010mimetic sonothermal platform through constructing metal\u2010semiconductor heterogeneous interface. Through magnetron sputtering on the surface of the sandblasted\/acid\u2010etched pretreated titanium (pTi), we find that semiconductor coatings (TiO\n                    <jats:sub>2<\/jats:sub>\n                    , Si, ZnO, and Te) endow pTi with different in situ sonothermal effects (\u0394T &gt; 18\u00b0C, 15\u00a0min) under ultrasound (US) irradiation, whereas conductor coatings do not. The sonothermal mechanism of pTi\u2010semiconductor is associated with US\u2010activated electron and phonon transport within the heterogeneous interface of implants, which is determined by the electrical and phonon characteristics of pTi\u2010semiconductor, including their matching degree, thermal conductivity, defected structure, and type of semiconductor. Clinical titanium screws were introduced with defected structure in oxygen layer (TiO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    ) and bone\u2010derived whitlockite, which shows great sonothermal\/sonodynamic effects for efficient elimination of biofilm infection and improved osseointegration. In addition, the prepared NiTi\u2010TiO\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    guidewire enables rapid thrombolysis (30\u00a0min) in the deep vein thrombosis of beagles after 10\u00a0min of sonothermal\/urokinase treatment. The electronic chip\u2010mimetic sonothermal platform provides a promising and widespread clinical application prospect.\n                  <\/jats:p>","DOI":"10.1002\/advs.77206","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T17:47:06Z","timestamp":1786816026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electronic Chip\u2010Mimetic Medical Implants for Controllable Sonothermal Treatments"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5869-6472","authenticated-orcid":false,"given":"Zhengdong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"},{"name":"School of Clinical Medicine, Chengdu Medical College, Department of Orthopedics, Development and Regeneration Key Laboratory of Sichuan Province The First Affiliated Hospital of Chengdu Medical College  Chengdu People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan People's Republic of China"},{"name":"Clinical Medical College &amp; 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