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Transarterial chemoembolization (TACE) remains standard treatment for intermediate\u2010stage HCC, but long\u2010term survival is poor. We aimed to develop a polymeric TACE\u2010like platform to sensitize liver cancer to checkpoint inhibitors by enabling sustained co\u2010delivery of panobinostat and IL\u201012.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    : Patient\u2010derived liver cancer organoids were used to screen drugs and identify panobinostat as a cytotoxic agent. We then formulated sustained\u2010release microparticles from anionic poly(lactic\u2010co\u2010glycolic acid) (PLGA) and cationic poly(beta\u2010amino ester) (PBAE) for combined delivery of panobinostat and IL\u201012, and tested the system in three liver cancer models.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : The microparticles achieved tumor\u2010specific retention and sustained release for two weeks following a single intratumoral or intrahepatic arterial injection. This led to tumor inhibition and prolonged survival in orthotopic liver cancer models. Mechanistically, treatment promoted tertiary lymphoid structure formation, increased infiltration of immune cells, and elevated pro\u2010inflammatory cytokines, triggering innate and adaptive antitumor immune responses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : A PLGA\/PBAE sustained\u2010release microparticle platform was successfully developed for TACE\u2010like co\u2010delivery of panobinostat and IL\u201012. This combined chemoimmunotherapy strategy shows promise for overcoming immune suppression and improving liver cancer treatment.\n                  <\/jats:p>","DOI":"10.1002\/advs.77223","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:09:46Z","timestamp":1787584186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Single\u2010Dose TACE\u2010Like Injection of Sustained\u2010Release Panobinostat\/IL\u201012 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models"],"prefix":"10.1002","author":[{"given":"Hongzhe","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Translational Tissue Engineering Center Johns Hopkins Translational ImmunoEngineering Center and the Institute for Nanobiotechnology Johns Hopkins University  Baltimore Maryland 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