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The probiotic\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    (AKK), known for its ability to modulate immune responses and suppress pathological inflammation, provides a promising immunomodulatory component to address these limitations. Here, an intravesical bacteria\u2010based chemo\u2010immunotherapeutic platform is developed by loading doxorubicin (DOX) onto pasteurized AKK modified with F127, yielding AKK\u2010F127\/DOX (AF\/D). Compared with free DOX, AF\/D more effectively inhibits bladder cancer cell proliferation, migration, and invasion, while inducing apoptosis, ferroptosis, immunogenic cell death, and suppressing the NF\u2010\u03baB inflammatory pathway. AF\/D also promotes dendritic\u2010cell maturation, pro\u2010inflammatory cytokine secretion, M1\u2010like macrophage polarization, antigen cross\u2010presentation, and tumor\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell priming. In orthotopic bladder cancer models, intravesical AF\/D shows superior antitumor efficacy and survival benefits over single\u2010agent treatments, remodels the local immune microenvironment, enhances systemic antigen\u2010specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses in the spleen, and maintains a favorable safety profile. These findings establish AF\/D as a promising intravesical chemo\u2010immunotherapeutic strategy for bladder cancer.\n                  <\/jats:p>","DOI":"10.1002\/advs.77241","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:53:17Z","timestamp":1786967597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Intravesical\n                    <i>Akkermansia muciniphila<\/i>\n                    \u2010Based Chemo\u2010Immunotherapeutic Platform for Bladder Cancer"],"prefix":"10.1002","author":[{"given":"Rongkang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology The Second Hospital &amp; Clinical Medical School Lanzhou University  Lanzhou China"},{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anguo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"},{"name":"Department of Urology The Fourth Affiliated Hospital of Soochow University Medical Center of Soochow University Suzhou Dushu Lake Hospital  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"},{"name":"Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National\u2010Regional Key Technology Engineering Laboratory for Medical Ultrasound School of Biomedical Engineering Shenzhen University Medical School  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3171-3137","authenticated-orcid":false,"given":"Lei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8292-4201","authenticated-orcid":false,"given":"Rui","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiadong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology South China Hospital Medical School Shenzhen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology The Second Hospital &amp; 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