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Although excessive reactive oxygen species (ROS) are recognized drivers of periodontal tissue damage, oxidative stress alone does not fully explain the persistence of inflammation and the failure of regeneration. The immune and metabolic processes that cooperate with oxidative stress in sustaining this disease\u2010supporting microenvironment remain incompletely defined. In this study, a pronounced T\n                    <jats:sub>H<\/jats:sub>\n                    17\u2010skewed CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell response is identified in experimental periodontitis, and enrichment of polyamine pathway activation is observed during T\n                    <jats:sub>H<\/jats:sub>\n                    17 differentiation, suggesting a candidate immunometabolic axis for intervention. Guided by this observation, difluoromethylornithine\u2010loaded UiO\u201066(Ce)\u2010Mn (DFMO@Ui\u2010Mn) is developed as a nanozyme platform that integrates the cascade ROS\u2010scavenging activity of UiO\u201066(Ce)\u2010Mn with DFMO delivery for inhibition of polyamine metabolism. DFMO@Ui\u2010Mn reduces T\n                    <jats:sub>H<\/jats:sub>\n                    17 polarization in vitro, alters polyamine\u2010related metabolic profiles, attenuates inflammatory responses in vivo, lowers the T\n                    <jats:sub>H<\/jats:sub>\n                    17\/Treg ratio, improves osteogenic readouts in a conditioned\u2010medium model, and promotes alveolar bone repair in ligature\u2010induced periodontitis. These findings support a therapeutic strategy that combines redox control with immunometabolic intervention to improve the periodontal microenvironment under inflammatory conditions.\n                  <\/jats:p>","DOI":"10.1002\/advs.77247","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:57:17Z","timestamp":1787050637000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T\n                    <sub>H<\/sub>\n                    17\u2013Associated Polyamine Metabolism\u2010Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis"],"prefix":"10.1002","author":[{"given":"Cheng","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Orthodontics College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong 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