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In this study, we find that chemotherapy induces an increased tumor neoantigens burden (TNB) in breast cancer patients and both non\u2010resistant and chemo\u2010resistant triple\u2010negative breast cancer 4T1 tumor\u2010bearing mice. Consistently, proteomic analysis reveals that tumor antigens derived from in vitro chemotherapy\u2010treated paclitaxel (PTX)\u2010resistant 4T1 cells (chemo\u2010rAg) are enriched in damage\u2010associated molecular patterns and neoantigens, highlighting their potential to elicit antitumor immunity against chemo\u2010resistant tumors. Based on these findings, we utilize the feature of PTX resistance and develop a nanovaccine incorporating chemo\u2010rAg and a prodrug of a toll\u2010like receptor 7 (TLR7) agonist. In preclinical mouse models, the nanovaccine effectively suppresses PTX\u2010resistant 4T1 tumor growth, and it also reverses the innate resistance of immune checkpoint inhibitors. Notably, the therapeutic benefit of the nanovaccine is augmented by chemotherapy, which facilitates in situ release of tumor antigens. 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