{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:33:44Z","timestamp":1787150024980,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102022\u2010NR067350"],"award-info":[{"award-number":["RS\u20102022\u2010NR067350"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102022\u201000164722"],"award-info":[{"award-number":["RS\u20102022\u201000164722"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201000518511"],"award-info":[{"award-number":["RS\u20102025\u201000518511"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201023324123"],"award-info":[{"award-number":["RS\u20102025\u201023324123"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Streptococci, Gram\u2010positive opportunistic pathogens, can cause inflammatory bone diseases, yet their virulence factors remain unclear. We investigated streptococcal components contributing to bone pathology. Unlike\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , streptococci and lipoprotein\u2010deficient strains induced comparable bone destruction and osteoclastogenesis in mice via a TLR2\u2010independent pathway. A comparative Q Exactive Plus mass spectrometric analysis of streptococcal and staphylococcal membrane proteins led us to identify mannose phosphotransferase system component IID (Man\u2010PTSIID) as a novel osteoclastogenic factor. Recombinant Man\u2010PTSIID and synthetic peptides containing conserved amino acid sequences of Man\u2010PTSIIDs found in various streptococci bound to the receptor activator of nuclear factor\u2010\u03baB (RANK), as demonstrated by an SPR analysis. Structural modeling and molecular docking analysis, together with full\u2010length Man\u2010PTSIID binding assays, demonstrated an interaction between Man\u2010PTSIID and RANK. Streptococcal Man \u2010 PTSIID promotes terminal osteoclast maturation and multinucleation following RANKL priming via the RANK signaling pathway, rather than mimicking native RANKL or functioning as an independent RANK agonist. Consistently, the osteoclastogenic effects induced by streptococci were not observed in Man\u2010PTSIID\u2010deficient mutant strains. Collectively, these findings suggest that Man\u2010PTSIID is a novel, differentiation stage\u2010dependent osteoclastogenic factor contributing to terminal osteoclast differentiation and plays a critical role in bone pathology during streptococcal infections.\n                  <\/jats:p>","DOI":"10.1002\/advs.77282","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T14:14:07Z","timestamp":1787148847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK\u2010Binding Osteoclastogenic Factor"],"prefix":"10.1002","author":[{"given":"Chaeyeon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Oral Microbiology and Immunology, and Dental Research Institute School of Dentistry Seoul National University  Seoul Republic of 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University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1350-6426","authenticated-orcid":false,"given":"Hyun Jung","family":"Ji","sequence":"additional","affiliation":[{"name":"Research Division For Radiation Science Korea Atomic Energy Research Institute  Jeongeup Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-8224","authenticated-orcid":false,"given":"Dongwook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology and Immunology, and Dental Research Institute School of Dentistry Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jueun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral Microbiology and Immunology, and Dental Research Institute School of Dentistry Seoul National University  Seoul Republic 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