{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:18:00Z","timestamp":1787984280743,"version":"build-2784847793"},"reference-count":72,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82500928"],"award-info":[{"award-number":["82500928"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi\u2010omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics. 16S sequencing and metagenomic analyses indicate that elevated isoalloLCA levels in CaOx rats or individuals are likely of microbial origin. Mechanistically, isoalloLCA binds to PARP1 via specific molecular interactions validated by surface plasmon resonance and cellular thermal shift assays. Knockdown of PARP1 by adeno\u2010associated virus microinjection or pharmacological inhibition with PARP1 inhibitor AZD5305 significantly attenuates isoalloLCA\u2010mediated crystal deposition, renal tubular injury, and mitochondrial functional impairment in both the CaOx rat and mouse models. Furthermore, the antibiotic\u2010mediated depletion of the gut microbiota in mice markedly reduced isoalloLCA levels, whereas fecal microbiota transplantationut contributes to isoalloLCA\u2010mediated CaOx stone formation, demonstrating a causal link between gut microbiota and isoalloLCA. In vitro, isoalloLCA promoted oxalate\u2010induced renal tubular epithelial cell injury and parthanatos via targeting PARP1, including DNA damage, excessive PARP1 activation, PAR accumulation, mitochondrial damage, nuclear translocation of AIF and MIF. These findings establish the microbiota\u2010isoalloLCA\u2010PARP1\u2010parthanatos axis in CaOx nephrolithiasis and identify PARP1 as a promising therapeutic target for kidney stone management.<\/jats:p>","DOI":"10.1002\/advs.77289","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:14:51Z","timestamp":1787984091000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut Microbiota\u2010Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1\u2010Mediated Parthanatos"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5202-1536","authenticated-orcid":false,"given":"Zijian","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Urology Huashan Hospital Fudan University  Shanghai P. R. China"},{"name":"Clinical Research Center of Urolithiasis Shanghai Medical College Fudan University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixi","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Urology Jiangnan University Medical Center  Wuxi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-8886","authenticated-orcid":false,"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Precision Research Center for Refractory Diseases Department of Urology Shanghai General Hospital Jiaotong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Shi","sequence":"additional","affiliation":[{"name":"Civil Aviation Shanghai Hospital Gubei Branch of Ruijin Hospital  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5862-9536","authenticated-orcid":false,"given":"Zeyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Nanjing First Hospital, Nanjing University of Chinese Medicine Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Urology Huashan Hospital Fudan University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Huashan Hospital Fudan University  Shanghai P. R. China"},{"name":"Clinical Research Center of Urolithiasis Shanghai Medical College Fudan University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0892-6102","authenticated-orcid":false,"given":"Ninghan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Urology Jiangnan University Medical Center  Wuxi P. R. China"},{"name":"Wuxi School of Medicine Jiangnan University  Wuxi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5103-9517","authenticated-orcid":false,"given":"Zhong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology Huashan Hospital Fudan University  Shanghai P. R. China"},{"name":"Clinical Research Center of Urolithiasis Shanghai Medical College Fudan University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3063-0874","authenticated-orcid":false,"given":"Dawei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/s41581-025-00990-x","article-title":"Kidney Stone Disease: Risk Factors, Pathophysiology and Management","volume":"21","author":"Bargagli M.","year":"2025","journal-title":"Nature Reviews Nephrology"},{"issue":"12","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41581-020-0320-7","article-title":"Determining the True Burden of Kidney Stone Disease","volume":"16","author":"Thongprayoon C.","year":"2020","journal-title":"Nature Reviews Nephrology"},{"issue":"3","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.advnut.2023.03.002","article-title":"Kidney Stone Prevention","volume":"14","author":"Peerapen P.","year":"2023","journal-title":"Advances in Nutrition"},{"issue":"7","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41585-020-0332-x","article-title":"Genetics of Kidney Stone Disease","volume":"17","author":"Howles S. A.","year":"2020","journal-title":"Nature Reviews Urology"},{"issue":"6","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41581-020-00392-1","article-title":"Randall's Plaque and Calcium Oxalate Stone Formation: Role for Immunity and Inflammation","volume":"17","author":"Khan S. R.","year":"2021","journal-title":"Nature Reviews Nephrology"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.redox.2018.03.019","article-title":"Autophagy Inhibition Attenuates Hyperoxaluria\u2010induced Renal Tubular Oxidative Injury and Calcium Oxalate Crystal Depositions in the Rat Kidney","volume":"16","author":"Duan X.","year":"2018","journal-title":"Redox Biology"},{"issue":"6","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103327","article-title":"Glomerulonephritis and Inflammatory Bowel Disease: a Tale of Gut\u2010kidney Axis Dysfunction","volume":"22","author":"Doumas S. A.","year":"2023","journal-title":"Autoimmunity Reviews"},{"issue":"12","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1136\/gutjnl-2017-315734","article-title":"Understanding the Gut\u2013kidney Axis in Nephrolithiasis: an Analysis of the Gut Microbiota Composition and Functionality of Stone Formers","volume":"67","author":"Ticinesi A.","year":"2018","journal-title":"Gut"},{"issue":"11","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/ki.2011.287","article-title":"Hyperoxaluria: a Gut\u2013kidney Axis?","volume":"80","author":"Robijn S.","year":"2011","journal-title":"Kidney International"},{"issue":"6","key":"e_1_2_12_11_1","article-title":"Short\u2010Chain Fatty Acids Reduced Renal Calcium Oxalate Stones by Regulating the Expression of Intestinal Oxalate Transporter SLC26A6","volume":"6","author":"Liu Y.","year":"2021","journal-title":"mSystems"},{"issue":"1","key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41392-023-01311-z","article-title":"Application of Metabolomics in Urolithiasis: the Discovery and Usage of succinate","volume":"8","author":"Zhang X. Z.","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"issue":"10","key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1681\/ASN.0000000000000421","article-title":"The Plasma Metabolome and Risk of Incident Kidney Stones","volume":"35","author":"Ferraro P. M.","year":"2024","journal-title":"Journal of the American Society of Nephrology"},{"issue":"11","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.cell.2024.03.034","article-title":"Gut Symbionts Alleviate MASH through a Secondary Bile Acid Biosynthetic Pathway","volume":"187","author":"Nie Q.","year":"2024","journal-title":"Cell"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2022.101210","article-title":"Bile Acids and Their Receptors in Regulation of Gut Health and Diseases","volume":"89","author":"Lin S.","year":"2023","journal-title":"Progress in Lipid Research"},{"issue":"4","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1097\/HEP.0000000000000611","article-title":"Bile Acid\u2013induced IRF3 Phosphorylation Mediates Cell Death, Inflammatory Responses, and Fibrosis in Cholestasis\u2010induced Liver and Kidney Injury via Regulation of ZBP1","volume":"79","author":"Zhuang Y.","year":"2024","journal-title":"Hepatology"},{"issue":"5","key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.apsb.2021.12.011","article-title":"Bile Acid Coordinates Microbiota Homeostasis and Systemic Immunometabolism in Cardiometabolic Diseases","volume":"12","author":"Guan B.","year":"2022","journal-title":"Acta Pharmaceutica Sinica B"},{"issue":"6","key":"e_1_2_12_18_1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0016-5085(76)80318-6","article-title":"Effect of Bile Salts and Fatty Acids on the Colonic Absorption of Oxalate","volume":"70","author":"Dobbins J. W.","year":"1976","journal-title":"Gastroenterology"},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110570","article-title":"Untargeted and Targeted Metabolomics Reveal Bile Acid Profile Changes in Rats with Ethylene Glycol\u2010induced Calcium Oxalate Nephrolithiasis","volume":"381","author":"Zhou Z.","year":"2023","journal-title":"Chemico\u2010Biological Interactions"},{"issue":"7","key":"e_1_2_12_20_1","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1161\/CIRCRESAHA.124.325642","article-title":"Multiomic Analysis of Calf Muscle in Peripheral Artery Disease and Chronic Kidney Disease","volume":"136","author":"Kim K.","year":"2025","journal-title":"Circulation Research"},{"issue":"1","key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1038\/s41467-023-38975-8","article-title":"A Spatially Anchored Transcriptomic Atlas of the human Kidney Papilla Identifies Significant Immune Injury in Patients with Stone Disease","volume":"14","author":"Canela V. H.","year":"2023","journal-title":"Nature Communications"},{"issue":"1","key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13059-025-03492-y","article-title":"Multi\u2010omics Analysis in Primary T Cells Elucidates Mechanisms behind Disease\u2010associated Genetic Loci","volume":"26","author":"Shi C.","year":"2025","journal-title":"Genome Biology"},{"issue":"3","key":"e_1_2_12_23_1","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2215\/CJN.07420619","article-title":"Proteomics and Metabolomics in Kidney Disease, Including Insights into Etiology, Treatment, and Prevention","volume":"15","author":"Dubin R. F.","year":"2020","journal-title":"Clinical Journal of the American Society of Nephrology"},{"issue":"2","key":"e_1_2_12_24_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.tips.2021.11.004","article-title":"Network Pharmacology: Curing Causal Mechanisms Instead of Treating Symptoms","volume":"43","author":"Nogales C.","year":"2022","journal-title":"Trends in Pharmacological Sciences"},{"issue":"2","key":"e_1_2_12_25_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133646","article-title":"Large\u2010scale Identification of Calcium Oxalate Stone Inhibitory Proteins in Normal human Urine","volume":"275","author":"Yoodee S.","year":"2024","journal-title":"International Journal of Biological Macromolecules"},{"issue":"41","key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"12197","DOI":"10.1021\/acs.jafc.1c03521","article-title":"Inhibitory Effects and Surface Plasmon Resonance\u2010Based Binding Affinities of Dietary Hydrolyzable Tannins and Their Gut Microbial Metabolites on SARS\u2010CoV\u20102 Main Protease","volume":"69","author":"Li H.","year":"2021","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"21","key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"4724","DOI":"10.1158\/1078-0432.CCR-22-0301","article-title":"Preclinical Characterization of AZD5305, a Next\u2010Generation, Highly Selective PARP1 Inhibitor and Trapper","volume":"28","author":"Illuzzi G.","year":"2022","journal-title":"Clinical Cancer Research"},{"issue":"1","key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13073-024-01370-z","article-title":"The PARP1 Selective Inhibitor saruparib (AZD5305) Elicits Potent and Durable Antitumor Activity in Patient\u2010derived BRCA1\/2\u2010associated Cancer Models","volume":"16","author":"Herencia\u2010Ropero A.","year":"2024","journal-title":"Genome Medicine"},{"key":"e_1_2_12_29_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113925","article-title":"Butyric Acid Inhibits Oxidative Stress and Inflammation Injury in Calcium Oxalate Nephrolithiasis by Targeting CYP2C9","volume":"178","author":"Zhou Z.","year":"2023","journal-title":"Food and Chemical Toxicology"},{"issue":"5","key":"e_1_2_12_30_1","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202304123","article-title":"Stanniocalcin\u20101 Promotes PARP1\u2010Dependent Cell Death via JNK Activation in Colitis","volume":"11","author":"Zhu L.","year":"2024","journal-title":"Advanced Science"},{"key":"e_1_2_12_31_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jare.2024.04.031","article-title":"Exploring the Role of Parthanatos in CNS Injury: Molecular Insights and Therapeutic Approaches","volume":"70","author":"Zhang J.","year":"2025","journal-title":"Journal of Advanced Research"},{"key":"e_1_2_12_32_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.metabol.2016.11.006","article-title":"The Role of Short\u2010chain Fatty Acids in Kidney Injury Induced by Gut\u2010derived Inflammatory Response","volume":"68","author":"Huang W.","year":"2017","journal-title":"Metabolism"},{"issue":"7885","key":"e_1_2_12_33_1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-021-03832-5","article-title":"Novel Bile Acid Biosynthetic Pathways Are Enriched in the Microbiome of Centenarians","volume":"599","author":"Sato Y.","year":"2021","journal-title":"Nature"},{"issue":"9","key":"e_1_2_12_34_1","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.chom.2021.07.013","article-title":"A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4A1","volume":"29","author":"Li W.","year":"2021","journal-title":"Cell Host & Microbe"},{"issue":"5","key":"e_1_2_12_35_1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1053\/j.ajkd.2023.03.017","article-title":"Kidney Stone Pathophysiology, Evaluation and Management: Core Curriculum 2023","volume":"82","author":"Shastri S.","year":"2023","journal-title":"American Journal of Kidney Diseases"},{"issue":"5","key":"e_1_2_12_36_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/MNH.0000000000000903","article-title":"Metabolomic Profiles and Pathogenesis of Nephrolithiasis","volume":"32","author":"Kowalczyk N. S.","year":"2023","journal-title":"Current Opinion in Nephrology & Hypertension"},{"key":"e_1_2_12_37_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.138629","article-title":"Exploring the Mechanism of Paotianxiong Polysaccharide in the Treatment of Chronic Kidney Disease Combining Metabolomics and Microbiomics Technologies","volume":"289","author":"Fu Q.","year":"2025","journal-title":"International Journal of Biological Macromolecules"},{"issue":"1","key":"e_1_2_12_38_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s42003-025-07641-8","article-title":"Activation of Gut Metabolite ACSL4\/LPCAT3 by Microplastics in Drinking Water Mediates Ferroptosis via Gut\u2013kidney Axis","volume":"8","author":"Zhang Y.","year":"2025","journal-title":"Communications Biology"},{"issue":"1","key":"e_1_2_12_39_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00240-024-01610-2","article-title":"Species\u2010level Characterization of Gut Microbiota and Their Metabolic Role in Kidney Stone Formation Using Full\u2010length 16S rRNA Sequencing","volume":"52","author":"Hussain B.","year":"2024","journal-title":"Urolithiasis"},{"issue":"8","key":"e_1_2_12_40_1","doi-asserted-by":"crossref","first-page":"11200","DOI":"10.1096\/fj.202000786R","article-title":"The Relationship between Gut Microbiota and Short Chain Fatty Acids in the Renal Calcium Oxalate Stones Disease","volume":"34","author":"Liu Y.","year":"2020","journal-title":"The FASEB Journal"},{"issue":"3","key":"e_1_2_12_41_1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1681\/ASN.2016020132","article-title":"Oxalobacter Formigenes\u2013Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells","volume":"28","author":"Arvans D.","year":"2017","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"e_1_2_12_42_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s40168-017-0316-0","article-title":"Oxalobacter Formigenes\u2010associated Host Features and Microbial Community Structures Examined Using the American Gut Project","volume":"5","author":"Liu M.","year":"2017","journal-title":"Microbiome"},{"issue":"1","key":"e_1_2_12_43_1","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1002\/j.2040-4603.2022.tb00199.x","article-title":"Oxalate Flux across the Intestine: Contributions from Membrane Transporters","volume":"12","author":"Whittamore J. M.","year":"2021","journal-title":"Comprehensive Physiology"},{"issue":"10","key":"e_1_2_12_44_1","first-page":"203","volume":"32","author":"Hassan H. A.","year":"2021","journal-title":"Journal of the American Society of Nephrology"},{"issue":"1","key":"e_1_2_12_45_1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1186\/s12866-025-04408-3","article-title":"A Novel Synbiotic Formulation Prevents Calcium Oxalate Stones by Restoring Gut Microbiota Homeostasis","volume":"25","author":"Li X. M.","year":"2025","journal-title":"BMC Microbiology"},{"issue":"1","key":"e_1_2_12_46_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00004836-198502000-00002","article-title":"Nephrolithiasis and Intestinal Disease","volume":"7","author":"Dobbins J. W.","year":"1985","journal-title":"Journal of Clinical Gastroenterology"},{"issue":"1","key":"e_1_2_12_47_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/ajcn\/30.1.64","article-title":"Hyperoxaluria and Calcium Oxalate Nephrolithiasis after Jejunoileal Bypass","volume":"30","author":"Stauffer J. Q.","year":"1977","journal-title":"The American Journal of Clinical Nutrition"},{"issue":"4","key":"e_1_2_12_48_1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.chom.2019.09.007","article-title":"Bioengineered Human Organ\u2010on\u2010Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection","volume":"26","author":"Grassart A.","year":"2019","journal-title":"Cell Host & Microbe"},{"issue":"1","key":"e_1_2_12_49_1","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1172\/JCI130976","article-title":"A Clostridia\u2010rich Microbiota Enhances Bile Acid Excretion in Diarrhea\u2010predominant Irritable Bowel Syndrome","volume":"130","author":"Zhao L.","year":"2020","journal-title":"Journal of Clinical Investigation"},{"issue":"7903","key":"e_1_2_12_50_1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41586-022-04480-z","article-title":"Human Gut Bacteria Produce \u03a4\u039717\u2010modulating Bile Acid Metabolites","volume":"603","author":"Paik D.","year":"2022","journal-title":"Nature"},{"issue":"6","key":"e_1_2_12_51_1","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101972RR","article-title":"Lactiplantibacillus Plantarum J\u201015 Reduced Calcium Oxalate Kidney Stones by Regulating Intestinal Microbiota, Metabolism, and Inflammation in Rats","volume":"36","author":"Tian L.","year":"2022","journal-title":"The FASEB Journal"},{"issue":"22","key":"e_1_2_12_52_1","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.9387","article-title":"Study on the Pathogenesis and Prevention Strategies of Kidney Stones Based on GC\u2013MS Combined with Metabolic Pathway Analysis","volume":"36","author":"Xie H.","year":"2022","journal-title":"Rapid Communications in Mass Spectrometry"},{"issue":"1","key":"e_1_2_12_53_1","doi-asserted-by":"crossref","DOI":"10.1038\/srep30142","article-title":"Metabolomics Analysis for Hydroxy\u2010L\u2010proline\u2010induced Calcium Oxalate Nephrolithiasis in Rats Based on Ultra\u2010high Performance Liquid Chromatography Quadrupole Time\u2010of\u2010flight Mass Spectrometry","volume":"6","author":"Gao S.","year":"2016","journal-title":"Scientific Reports"},{"issue":"1","key":"e_1_2_12_54_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jhep.2024.09.032","article-title":"Bile Acid Metabolism and Signalling in Liver Disease","volume":"82","author":"Fuchs C. D.","year":"2025","journal-title":"Journal of Hepatology"},{"issue":"2","key":"e_1_2_12_55_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1152\/physrev.00049.2019","article-title":"Molecular Physiology of Bile Acid Signaling in Health, Disease, and Aging","volume":"101","author":"Perino A.","year":"2021","journal-title":"Physiological Reviews"},{"issue":"3","key":"e_1_2_12_56_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.molmed.2021.12.006","article-title":"Crosstalk between Bile Acid\u2010activated Receptors and Microbiome in Entero\u2010hepatic Inflammation","volume":"28","author":"Thibaut M. M.","year":"2022","journal-title":"Trends in Molecular Medicine"},{"key":"e_1_2_12_57_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101755","article-title":"TRPM2 channel\u2010mediated Cell Death: an Important Mechanism Linking Oxidative Stress\u2010inducing Pathological Factors to Associated Pathological Conditions","volume":"37","author":"Malko P.","year":"2020","journal-title":"Redox Biology"},{"issue":"3","key":"e_1_2_12_58_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.kint.2024.04.015","article-title":"Tauroursodeoxycholic Acid Ameliorates Renal Injury Induced by COL4A3 Mutation","volume":"106","author":"Yu S.","year":"2024","journal-title":"Kidney International"},{"key":"e_1_2_12_59_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejphar.2018.09.009","article-title":"Farnesoid X Receptor Agonist Obeticholic Acid Inhibits Renal Inflammation and Oxidative Stress during Lipopolysaccharide\u2010induced Acute Kidney Injury","volume":"838","author":"Zhu J. B.","year":"2018","journal-title":"European Journal of Pharmacology"},{"issue":"5","key":"e_1_2_12_60_1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1681\/ASN.2014121271","article-title":"G Protein\u2010Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes","volume":"27","author":"Wang X. X.","year":"2016","journal-title":"Journal of the American Society of Nephrology"},{"issue":"7","key":"e_1_2_12_61_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115936","article-title":"Gut Microbiota\u2010bile Acid Crosstalk Contributes to Calcium Oxalate Nephropathy through Hsp90\u03b1\u2010mediated Ferroptosis","volume":"44","author":"Liu L.","year":"2025","journal-title":"Cell Reports"},{"issue":"7785","key":"e_1_2_12_62_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-019-1785-z","article-title":"Bile Acid Metabolites Control TH17 and Treg Cell Differentiation","volume":"576","author":"Hang S.","year":"2019","journal-title":"Nature"},{"issue":"9","key":"e_1_2_12_63_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nchembio.1864","article-title":"A Biosynthetic Pathway for a Prominent Class of Microbiota\u2010derived Bile Acids","volume":"11","author":"Devlin A. S.","year":"2015","journal-title":"Nature Chemical Biology"},{"issue":"10","key":"e_1_2_12_64_1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrm.2017.53","article-title":"The Multifaceted Roles of PARP1 in DNA Repair and Chromatin Remodelling","volume":"18","author":"Chaudhuri A. R.","year":"2017","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"e_1_2_12_65_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2021.101117","article-title":"PARPs in Lipid Metabolism and Related Diseases","volume":"84","author":"Szanto M.","year":"2021","journal-title":"Progress in Lipid Research"},{"issue":"5","key":"e_1_2_12_66_1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/lary.30284","article-title":"The Role of PARP \u20101 and NF\u2010\u03baB in Bile\u2010Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells","volume":"133","author":"Doukas P. G.","year":"2023","journal-title":"The Laryngoscope"},{"issue":"6308","key":"e_1_2_12_67_1","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1126\/science.aad6872","article-title":"A Nuclease That Mediates Cell Death Induced by DNA Damage and Poly(ADP\u2010ribose) Polymerase\u20101","volume":"354","author":"Wang Y.","year":"2016","journal-title":"Science"},{"issue":"4","key":"e_1_2_12_68_1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/ki.2014.388","article-title":"Necroptosis and Parthanatos Are Involved in Remote Lung Injury after Receiving Ischemic Renal Allografts in Rats","volume":"87","author":"Zhao H.","year":"2015","journal-title":"Kidney International"},{"issue":"6","key":"e_1_2_12_69_1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s43587-024-00627-x","article-title":"Converting Cell Death into Senescence by PARP1 Inhibition Improves Recovery from Acute Oxidative Injury","volume":"4","author":"Nehme J.","year":"2024","journal-title":"Nature Aging"},{"issue":"1","key":"e_1_2_12_70_1","doi-asserted-by":"crossref","DOI":"10.1590\/1678-4685-gmb-2023-0357","article-title":"Molecular Mechanisms of Cell Death by Parthanatos: More Questions than Answers","volume":"47","author":"Moura R. D.","year":"2024","journal-title":"Genetics and Molecular Biology"},{"issue":"1","key":"e_1_2_12_71_1","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10274","article-title":"Cytotoxicity of Crystals Involves RIPK3\u2010MLKL\u2010mediated Necroptosis","volume":"7","author":"Mulay S. R.","year":"2016","journal-title":"Nature Communications"},{"issue":"4","key":"e_1_2_12_72_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nrneph.2017.10","article-title":"Crystal Nephropathies: Mechanisms of Crystal\u2010induced Kidney Injury","volume":"13","author":"Mulay S. R.","year":"2017","journal-title":"Nature Reviews Nephrology"},{"issue":"1","key":"e_1_2_12_73_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/0115680096327635241021115944","article-title":"Clinical Application of PARP1 Inhibitors and Challenges in Cancer Therapy","volume":"26","author":"Luo Y.","year":"2026","journal-title":"Current Cancer Drug Targets"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77289","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.77289","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:15:01Z","timestamp":1787984101000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":72,"alternative-id":["10.1002\/advs.77289"],"URL":"https:\/\/doi.org\/10.1002\/advs.77289","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]},"assertion":[{"value":"2026-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e77289"}}