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However, it still suffers from heterogeneous therapeutic outcomes and potential immune\u2010related adverse events (irAEs). Inspired by a natural phenomenon that microalgae can absorb and accumulate selenium (Se), a well\u2010known healthcare element, we engineered a Se\u2010enriched cyanobacterium\n                    <jats:italic>Synechococcus Sp<\/jats:italic>\n                    (Se\u2010\n                    <jats:italic>Ssp<\/jats:italic>\n                    ) for advanced immunotherapy. Simply by culturing in the presence of Na\n                    <jats:sub>2<\/jats:sub>\n                    SeO\n                    <jats:sub>3<\/jats:sub>\n                    , Se nanoparticles could be bio\u2010fabricated within\n                    <jats:italic>Synechococcus Sp<\/jats:italic>\n                    , underscoring a facile preparation process with promising translational potential. With satisfactory biocompatibility and internalization efficiency, Se\u2010\n                    <jats:italic>Ssp<\/jats:italic>\n                    boosted dendritic cell maturation and antigen presentation via both the Toll\u2010like receptor and the cyclic GMP\u2010AMP synthase\u2010stimulator of interferon genes (cGAS\u2010STING) pathways, likely attributed to the Se\u2010enhanced influx of calcium. In vivo studies demonstrated that Se\u2010\n                    <jats:italic>Ssp<\/jats:italic>\n                    elicited potent innate immunity and maintained long\u2010term adaptive immunity, effectively inhibiting tumor growth with sustained protection against recurrence. In addition, Se\u2010\n                    <jats:italic>Ssp<\/jats:italic>\n                    was validated to sensitize the reaction of both primary and distant tumors to immune checkpoint and indoleamine 2,3\u2010dioxygenase inhibitors; it also restrained the progression of orthotopic bladder carcinoma via intravesical instillation as well. Briefly, this study developed an anti\u2010cancer immune application of engineered Se\u2010\n                    <jats:italic>Ssp<\/jats:italic>\n                    , offering a promising alternative with significant therapeutic potential that might benefit patients with cancer.\n                  <\/jats:p>","DOI":"10.1002\/advs.77297","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:43:06Z","timestamp":1787845386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Natural\u2010Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti\u2010Tumor Immunity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9224-6987","authenticated-orcid":false,"given":"Yuqi","family":"Yang","sequence":"first","affiliation":[{"name":"Institute of Functional Nano &amp; Soft Materials (FUNSOM) Jiangsu Key Laboratory of Advanced Healthcare Materials &amp; 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