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While micron\u2010sized condensates are observed above a well\u2010defined saturation concentration, the formation of nanoscale clusters also occurs at subsaturated concentrations. The diversity and physical nature of such nanoscale clusters remain underexplored with respect to the well\u2010established condensate state. Here we show that the Parkinson's disease\u2010associated protein \u03b1\u2010synuclein forms highly monodisperse assemblies at low ionic strength, distinct from the larger polydisperse assemblies previously observed at higher ionic strengths. Using a range of biophysical methods, we identify monodisperse clusters of \u03b1\u2010synuclein composed of \u223c20 molecules that maintain their size over a broad concentration range. These clusters are stable over time and do not progress to amyloid fibril formation. Their response to mutational perturbations and chemical destabilization, as well as their thermal cycling support a micelle\u2010like assembly. Increasing ionic strength shifts the system toward the formation of larger, polydisperse nanoclusters and condensates that promote amyloid fibril formation. Our results reveal a hitherto uncharacterized assembly state of \u03b1\u2010synuclein and highlight the complexity of nanoscale assembly processes by IDPs.<\/jats:p>","DOI":"10.1002\/advs.77300","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:49:46Z","timestamp":1787323786000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u03b1\u2010Synuclein Forms Distinct Micelle\u2010Like Assemblies at Low Ionic Strengths"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3428-3352","authenticated-orcid":false,"given":"Sophie","family":"Hertel","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Biomedicine Technical University of Denmark, Kgs  Lyngby 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