{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:05:57Z","timestamp":1789725957752,"version":"4.0.1"},"reference-count":55,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this work, we investigate a novel photochromic azobenzene derivative,\n                    <jats:bold>TC827<\/jats:bold>\n                    , which exhibits a unique photoelectric response when embedded in artificial lipid membranes. By combining spectroscopic, electrochemical, and molecular simulation analyses, we demonstrate that\n                    <jats:bold>TC827<\/jats:bold>\n                    forms light\u2010controlled \u201cmolecular wires\u201d in its trans conformation, resulting in a significant increase in membrane conductivity under dark conditions, which is fully reversible, as light\u2010induced cis isomerization suppresses the conductivity enhancement. This behavior is fundamentally different from previously studied amphiphilic azobenzene derivatives, whose effect on lipid membranes is usually attributed to their ability to increase permeability by disrupting membrane packing, leading to a current increase in the cis state under irradiation. In our system, the increase in conductivity is not associated with membrane destabilization due to the chemical structure of\n                    <jats:bold>TC827<\/jats:bold>\n                    molecule, which lacks long alkyl chains and features a \u03c0\u2010conjugated structure. These findings underline the potential of structurally simple, short\u2010chain photo\u2010switchable molecules to modulate membrane properties through charge transport mechanisms induced by light, offering a new pathway toward the design of optoelectronic bio\u2010interfaces.\n                  <\/jats:p>","DOI":"10.1002\/advs.77303","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:40:11Z","timestamp":1787323211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Light\u2010Controlled Conductive Molecular Wire in an Artificial Lipid Membrane"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-6028","authenticated-orcid":false,"given":"Ilaria","family":"Cardace","sequence":"first","affiliation":[{"name":"CNR\u2010NANOTEC Institute of Nanotechnology  Lecce (LE) 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