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To address these issues, we designed a multifunctional hydrogel (named SEH) loaded with a novel cyanine nanozyme and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ). The cyanine nanozyme integrates efficient photothermal therapy (PTT), photodynamic therapy (PDT), and peroxidase\u2010like enzyme activity. SEH is a temperature\u2010sensitive agarose hydrogel. Upon light irradiation, PTT and PDT are simultaneously triggered, inducing hydrogel degradation to release the encapsulated nanozymes and\n                    <jats:italic>E. coli<\/jats:italic>\n                    . PTT and PDT jointly kill residual tumor cells and\n                    <jats:italic>E. coli<\/jats:italic>\n                    , and the death of the latter\u00a0leads to the release of pathogen\u2010associated molecular patterns (PAMPs). The nanozymes combined with PDT cyclically produce more reactive oxygen species\u00a0to deplete extracellular GSH, which disrupts the redox balance of residual tumor cells. Furthermore, released PAMPs recruit immune cells to the tumor site, thereby activating anti\u2010tumor immune responses and establishing long\u2010term immune protection. This study provides a novel and effective strategy for postoperative tumor therapy and recurrence inhibition.\n                  <\/jats:p>","DOI":"10.1002\/advs.77309","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:59:26Z","timestamp":1788497966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organic Nanozyme\u2010Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression"],"prefix":"10.1002","author":[{"given":"Cong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Breast Surgery The Third Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital Peking University Cancer Hospital Yunnan  Kunming Yunnan P. R. 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