{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:33:56Z","timestamp":1790555636192,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173454"],"award-info":[{"award-number":["82173454"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574029"],"award-info":[{"award-number":["82574029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504333"],"award-info":[{"award-number":["82504333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103783"],"award-info":[{"award-number":["82103783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Radiation\u2010induced pulmonary fibrosis, a devastating thoracic radiotherapy sequela, features aberrant ECM deposition and irreversible loss of functional lung architecture. However, the exact molecular mechanisms governing AECII dysfunction and fate transition during RIPF remain poorly understood. Here, we identify a novel metabolic\u2010epigenetic\u2010epitranscriptomic cascade that orchestrates the pro\u2010fibrotic fate of AECIIs. We demonstrate that radiation exposure triggers a glycolytic shift in AECIIs, resulting in pathological intracellular lactate accumulation. This metabolic stress is directly coupled to chromatin remodeling via p300\u2010mediated H3K18la at the\n                    <jats:italic>VIRMA<\/jats:italic>\n                    promoter, driving its robust transcriptional activation. Consequently, elevated VIRMA promotes a pro\u2010fibrotic epitranscriptomic landscape by increasing m6A enrichment on the\n                    <jats:italic>GATA3<\/jats:italic>\n                    mRNA. Recognition of this modification by the m6A reader YTHDF1 extends\n                    <jats:italic>GATA3<\/jats:italic>\n                    mRNA half\u2010life. The ensuing GATA3 accumulation initiates EMT and exacerbates ECM deposition. Strikingly, utilizing AECII\u2010specific Virma conditional knockout mice, we confirmed the essential role of this axis in vivo; genetic ablation of Virma preserved alveolar integrity and conferred resistance to radiation\u2010induced fibrogenesis. Furthermore, pharmacological inhibition of the H3K18la writer p300 using C646 abrogated the fibrotic phenotype. Collectively, our findings elucidate how radiation\u2010induced metabolic reprogramming is durably inscribed into the epigenome to dictate cell fate, offering a therapeutic rationale for targeting the H3K18la\/VIRMA\/GATA3 axis in RIPF.\n                  <\/jats:p>","DOI":"10.1002\/advs.77328","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:09:40Z","timestamp":1787584180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["p300\u2010Mediated H3K18 Lactylation Drives Radiation\u2010Induced Pulmonary Fibrosis via VIRMA\u2010Dependent m6A Modification of GATA3"],"prefix":"10.1002","author":[{"given":"Junxuan","family":"Yi","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Radiobiology School of Public Health Jilin University  Changchun Jilin 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School of Public Health Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Li","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Radiobiology School of Public Health Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Han","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Nuclear Technology Medical Transformation Mianyang Central Hospital  Mianyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-0069","authenticated-orcid":false,"given":"Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Senior Department of Oncology the Fifth Medical Center of PLA General Hospital Beijing 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