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In this study, we identified the dysregulated repair program of Schwann cells (SCs) as a key feature of the aging\u2010dependent impairment of nerve regeneration, mediated by dual influence of ferroptosis. The ferroptosis\u2010stressor\u2010rich microenvironment inhibits SC function in regenerating nerves. Moreover, the persistent intracellular ferroptosis stressor accumulation could accentuate senescence\u2010associated secretory phenotype (SASP) expression in SCs, culminating in the disruption of redifferentiation trajectory and repair programs of SCs. Herein, a composite nerve conduit integrating microenvironment\u2010responsive Ga\u2010PTA nanoparticles and maxillofacial\u2010derived mesenchymal stem cells (Mmscs) is developed by melt electrospinning writing (MEW). Mechanistically, Ga\u2010PTA nanoparticles competitively inhibited excessive ferroptosis to establish a pro\u2010regenerative niche. Meanwhile, Mmscs was induced to differentiate into SC\u2010like cells which bypassed the redifferentiation impairment of resident SASP\u2010expressing SCs, offering promising therapeutic strategies for peripheral nerve and other tissue injuries during aging.<\/jats:p>","DOI":"10.1002\/advs.77351","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:12:24Z","timestamp":1787663544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Microenvironment\u2010Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells"],"prefix":"10.1002","author":[{"given":"Ning","family":"Zhan","sequence":"first","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"},{"name":"Department of Plastic Surgery The First Affiliated Hospital School of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical Engineering Zhejiang Key Laboratory of Additive Manufacturing Technology and Equipment School of Mechanical Engineering Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjie","family":"Peng","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lining","family":"Lin","sequence":"additional","affiliation":[{"name":"Stomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University 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