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Its episodic and fluctuating nature complicates diagnosis and management, as conventional clinical assessments often fail to capture transient tear film changes. Although emerging tear\u2010sensing technologies show promise, many rely on trained personnel, only sporadic measurements, external readers, or integrated electronics, limiting their practicality for in\u2010eye applications. Here, we present an electronics\u2010free scleral lens platform for wearable monitoring of DED\u2010related tear biomarker changes using passive colorimetric sensors integrated within the lens tear reservoir. This configuration enables visual and smartphone\u2010assisted readout of chloride ions, pH, and ocular surface temperature within physiologically relevant ranges while avoiding direct contact with the corneal surface. The vaulted scleral lens geometry forms a stable, self\u2010replenishing tear reservoir that concentrates biomarkers while shielding sensors from corneal contact and eyelid pressure. Sensor color changes are directly observable and quantifiable via a smartphone without specialized readers or user\u2010specific calibration. Validated using artificial tear fluids, human tear samples, and in vivo models, this platform enables wearable monitoring of DED\u2010related biomarkers within physiologically relevant ranges, offering a simple and clinically viable approach for tracking ocular surface conditions and associated treatment efficacy.<\/jats:p>","DOI":"10.1002\/advs.77399","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:59:28Z","timestamp":1787846368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Electronics\u2010Free Visual Monitoring of Dry Eye Disease\u2010Related Tear Biomarkers Using Smart Scleral Lenses"],"prefix":"10.1002","author":[{"given":"Ziheng","family":"Wang","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering Purdue University  West Lafayette Indiana 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