{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:59:07Z","timestamp":1792814347625,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470724"],"award-info":[{"award-number":["82470724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Impaired wound healing in diabetes is closely associated with cellular ferroptosis. Microneedle\u2010assisted gas therapy exerts molecular regulation of ferroptosis, representing a promising approach for accelerating diabetic wound healing. To date, O\n                    <jats:sub>2<\/jats:sub>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    gas therapies have consistently been conducted independently and have never been integrated into a single system. Whether and how their synergy might be realized remains a defining challenge. Herein, we propose a concept of integrated O\n                    <jats:sub>2<\/jats:sub>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    gas therapy, demonstrated by fabricating a gas\u2010producing microneedle material. Platinum@MIL\u2010101(Fe)\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    @phosphotungstic acid (PMP) nanoparticles are synthesized as a visible light\u2010driven photocatalyst for H\n                    <jats:sub>2<\/jats:sub>\n                    and O\n                    <jats:sub>2<\/jats:sub>\n                    co\u2010evolution. The rational design of a spatially separated structure boosts their photocatalytic efficiency under physiological conditions. PMP nanoparticles are further incorporated with bilayer gelatin methacryloyl (GelMA)\/PMP composite microneedles (denoted as GPM microneedles). The obtained GPM microneedles enable transdermal delivery of PMP nanoparticles for integrated O\n                    <jats:sub>2<\/jats:sub>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    gas therapy, and demonstrate desirable biocompatibility and pro\u2010regenerative effects. The mechanism of integrated O\n                    <jats:sub>2<\/jats:sub>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    gas therapy has been identified as a TNFAIP3\/hnRNPA1 ubiquitination\/ferroptosis signaling axis, establishing for the first time a direct link to ferroptosis. In conclusion, this study yields a transformative concept and a ferroptosis\u2010targeting microneedle material with well\u2010defined molecular mechanism for diabetic wound management.\n                  <\/jats:p>","DOI":"10.1002\/advs.77413","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:43:06Z","timestamp":1787989386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated O\n                    <sub>2<\/sub>\n                    and H\n                    <sub>2<\/sub>\n                    Gas Therapy via Microneedle\u2010Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full\u2010Thickness Skin Wound Healing"],"prefix":"10.1002","author":[{"given":"Zesheng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology Hubei Key Laboratory of Urological Diseases Institute of Urology Zhongnan Hospital of Wuhan University  Wuhan 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