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This challenge is acute during biological invasions, where exposure to novel microbial communities can outpace host genetic adaptation.\n                    <jats:italic>Dendroctonus valens<\/jats:italic>\n                    (RTB) associates with its mutualistic fungus\n                    <jats:italic>Leptographium procerum<\/jats:italic>\n                    (Lp), forming an invasive beetle\u2013fungus complex during attacks on Chinese pines. Lp fails to trigger antimicrobial peptide expression but induces the heat shock protein 83 (HSP83). The native antagonist\n                    <jats:italic>Ophiostoma minus<\/jats:italic>\n                    (Om) activates immunity through pattern recognition receptors, including PGRP\u2010SA, PGRP\u2010SC2, \u03b2GRP3, and \u03b2GRP5. HSP83 modulates these responses through two\u2010tiered negative regulation. First, it associates with PGRP\u2010SA, \u03b2GRP3, and \u03b2GRP5 to attenuate Om detection. Second, it interacts with NF\u2010\u03baB\u2013like factor Dorsal to limit antimicrobial peptide production. This symbiont\u2010induced regulation enables selective defense, supporting RTB survival during combined Lp and Om exposure while limiting excessive Toll\u2010dependent PRR\/AMP activation and easing immune\u2013metabolic trade\u2010offs. These findings define a symbiont\u2010assisted, mutation\u2010independent mechanism of host adjustment during biological invasions, in which microbial partners provide immediate immune benefits and influence host success in novel environments.\n                  <\/jats:p>","DOI":"10.1002\/advs.77421","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:16:09Z","timestamp":1787843769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symbiont\u2010Induced HSP83 Establishes Two\u2010Tiered Control of Antifungal Immunity in an Invasive Beetle\u2013Fungus Complex"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3627-4242","authenticated-orcid":false,"given":"Qingtai","family":"Yang","sequence":"first","affiliation":[{"name":"Hebei Basic Science Center For Biotic Interactions School of Life Sciences Institutes of Life Science and Green Development Hebei 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