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We assessed nanoparticle distribution after injecting iron oxide nanoparticles conjugated with either a monoclonal anti\u2010HER2 (human epidermal growth factor 2), or a non\u2010specific IgG antibody into a human HER2 overexpressing murine breast cancer model. We used Magnetic Particle Imaging (MPI) and histopathology to assess particle localization at 72\u00a0h after injection. MPI detects magnetic moments produced by magnetic particles, and histology enables spatial quantification of nanoparticles. Intratumor iron content measured by MPI correlated with inductively coupled plasma mass spectrometry (\n                    <jats:italic>\u03c1<\/jats:italic>\n                    = 0.868,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.0001). We detected nanoparticle accumulation in tumors, and organs and tissues associated with inflammation. MPI showed higher uptake of nanoparticles in tumors, regardless of their performance in vitro. Spatial analysis showed that 43 \u00b1 7% of nanoparticles that reached the tumor accumulated in the peripheral quartile of the tumor, with decreasing amounts toward the center. Immunohistochemical analysis showed the nanoparticles were strongly associated with inflammatory immune and stromal cells in the tumor microenvironment. This hyperintense peripheral accumulation, or ring pattern, observed with MPI enabled us to distinguish tumors from general inflammation. Iron oxide nanoparticle\u2010mediated MPI has the potential to detect tumors, providing another powerful diagnostic tool.\n                  <\/jats:p>","DOI":"10.1002\/advs.77425","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T16:44:09Z","timestamp":1788108249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyper\u2010Intense Tumor Peripheral Accumulation of Antibody\u2010Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-493X","authenticated-orcid":false,"given":"Preethi","family":"Korangath","sequence":"first","affiliation":[{"name":"Deptartment of Radiation Oncology and Molecular Radiation Sciences School of Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden","family":"Carlton","sequence":"additional","affiliation":[{"name":"Deptartment of Radiation Oncology and Molecular Radiation Sciences School of Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6014-5783","authenticated-orcid":false,"given":"Theresa","family":"Wong","sequence":"additional","affiliation":[{"name":"Deptartment of Radiation Oncology and Molecular Radiation Sciences School of Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Healy","sequence":"additional","affiliation":[{"name":"Deptartment of Radiation Oncology and Molecular Radiation Sciences School of Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Sanders","sequence":"additional","affiliation":[{"name":"Magnetic Insight Inc.  Alameda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason","family":"Song","sequence":"additional","affiliation":[{"name":"Deptartment of Radiation Oncology and Molecular Radiation Sciences School of Medicine Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Goodwill","sequence":"additional","affiliation":[{"name":"Magnetic Insight Inc.  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