{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:19:14Z","timestamp":1788002354432,"version":"build-2784847793"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["ZYGX2021YGCX001"],"award-info":[{"award-number":["ZYGX2021YGCX001"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["ZH2023\u2010801"],"award-info":[{"award-number":["ZH2023\u2010801"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020207","name":"Health Commission of Sichuan Province","doi-asserted-by":"publisher","award":["24QNMP038"],"award-info":[{"award-number":["24QNMP038"]}],"id":[{"id":"10.13039\/501100020207","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Acute radiation\u2010induced lung injury (RILI) remains a major dose\u2010limiting complication of thoracic radiotherapy with limited therapeutic options. Here, we develop an inhalable nanoformulation of the traditional Chinese medicine Huaxian Formula (NHXF) with favorable physicochemical stability and enhanced pulmonary delivery properties. In vitro and in vivo studies demonstrate that NHXF attenuates radiation\u2010induced alveolar epithelial injury, accompanied by reductions in oxidative stress and apoptosis. NHXF also suppresses secondary inflammatory responses, as evidenced by decreased pro\u2010inflammatory cytokine production and neutrophil infiltration, which may contribute to its protective effects against acute RILI. Importantly, NHXF displays a favorable safety profile throughout treatment. Transcriptomic analysis highlights ferroptosis\u2010related pathways associated with NHXF\u2010mediated protection. Our findings indicate that NHXF treatment is associated with the attenuation of ferroptosis\u2010related alterations in iron homeostasis and lipid peroxidation. Pharmacological activation of ferroptosis significantly diminishes the protective effects of NHXF against radiation\u2010induced injury, further supporting a functional contribution of ferroptosis modulation to NHXF\u2010mediated protection, while acknowledging that additional direct mechanistic evidence is warranted to establish causal dependency. Collectively, these findings support NHXF as a potential inhalable nanotherapeutic for acute RILI and highlight pulmonary delivery of nanoformulated traditional Chinese medicine combined with ferroptosis modulation as a promising strategy for RILI management.<\/jats:p>","DOI":"10.1002\/advs.77472","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:10:40Z","timestamp":1788001840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Huaxian Formula Nanoformulation Confers Protection Against Acute Radiation\u2010Induced Lung Injury by Targeting Ferroptosis"],"prefix":"10.1002","author":[{"given":"Li","family":"Quan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Precision Radiation in Oncology Key Laboratory of Sichuan Province Sichuan Clinical Research Center for Cancer Sichuan Cancer Center Sichuan Cancer Hospital &amp; Institute Affiliated Cancer 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