{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T06:03:11Z","timestamp":1789365791683,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T00:00:00Z","timestamp":1789257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE\u20102213445"],"award-info":[{"award-number":["CHE\u20102213445"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM113123"],"award-info":[{"award-number":["P20GM113123"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54GM128729"],"award-info":[{"award-number":["U54GM128729"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Synergistic chemo\u2010photodynamic therapy has been proven more effective for cancer treatment compared to traditional chemotherapy and photodynamic therapy alone. Leveraging the characteristic of cancer cells that glutathione (GSH) plays an indispensable role in the development of drug resistance and reactive oxygen species (ROS) neutralization, we developed a carrier\u2010free GSH\u2010consuming theranostic nanoprodrug to deeply explore the GSH\u2010consumption\u2010promoted synergistic chemo\u2010photodynamic therapy for boosted cancer treatment. The GSH\u2010consuming nanoprodrug consists of paclitaxel (PTX) and a boron\u2010dipyrromethene (BODIPY)\u2010based photosensitizer, linked through a GSH\u2010responsive self\u2010immolating drug linkage; to serve as a control, a non\u2010GSH\u2010consuming nanoprodrug consisting of those two moieties linked by a non\u2010biocleavable linkage was also developed. The carrier\u2010free nanoprodrugs have a diameter of \u223c65\u00a0nm and an ultrahigh drug loading content (&gt;70%), and have exhibited highly efficient suppression against tumor proliferation upon light irradiation to trigger their photodynamic effect, more potent than the free PTX drug, because of the synergistic chemo\u2010photodynamic therapy. Attractively, the GSH\u2010consuming theranostic nanoprodrug, in comparison with its non\u2010GSH\u2010consuming counterpart, exerted extraordinarily powerful therapeutic effects, benefiting from its integrated advantages, including GSH\u2010activated traceless PTX release, reduced drug resistance, and disabled ROS neutralization of cancer cells due to the consumption of intracellular GSH, resulting in the ultimate eradication of tumors.<\/jats:p>","DOI":"10.1002\/advs.77484","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:20:10Z","timestamp":1789363210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Carrier\u2010Free Stimulus\u2010Responsive Theranostic Nanoprodrug Enabling GSH\u2010Consumption\u2010Promoted Chemo\u2010Photodynamic Cancer Therapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7775-1558","authenticated-orcid":false,"given":"Hansheng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Chemistry University of North Dakota  Grand Forks North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-317X","authenticated-orcid":false,"given":"Binglin","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of North Dakota  Grand Forks North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201600106"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00215A"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CC02816G"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.08.054"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900132"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.7150\/thno.54227","article-title":"Recent Advances in Innovative Strategies for Enhanced Cancer Photodynamic Therapy","volume":"11","author":"Hu T.","year":"2021","journal-title":"Theranostics"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB01466H"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB02248F"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC04608K"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.108594"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214636"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00116"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2010.04.009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216643"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CS00521K"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2SC01003H"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05341"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.8b00737"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5TB01434D"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c16585"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5728"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ajps.2019.06.003","article-title":"Redox Dual\u2010Stimuli Responsive Drug Delivery Systems for Improving Tumor\u2010Targeting Ability and Reducing Adverse Side Effects","volume":"15","author":"Li R.","year":"2020","journal-title":"Asian Journal of Pharmaceutical Sciences"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b06400"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB00009F"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.08.013"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","DOI":"10.1021\/acsanm.3c03510","article-title":"Nanomicelle\u2010Based Redox\u2010Responsive Dual\u2010Prodrug for Synergistic Breast Cancer Chemo\u2010Immunotherapy","volume":"6","author":"Zhang L.","year":"2023","journal-title":"ACS Applied Nano Materials"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.128880"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00406"},{"key":"e_1_2_8_30_1","first-page":"24397","article-title":"Disulfide Based Prodrugs for Cancer Therapy","volume":"10","author":"Wang Q.","year":"2020","journal-title":"Royal Society of Chemistry Advances"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.1c00326"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202501420"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35216H"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201602162"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201403600"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/am506262u"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00991A"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB01650E"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4TB02782E"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201601054"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214908"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102368"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00456B"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202525491"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC01171A"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202002843"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.028"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.03.012"},{"key":"e_1_2_8_49_1","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.1021\/acsanm.1c00987","article-title":"Nanoparticle Size Effects in Biomedical Applications","volume":"4","author":"Dolai J.","year":"2021","journal-title":"ACS Applied Nano Materials"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202104632"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.77484","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:20:12Z","timestamp":1789363212000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,13]]},"references-count":49,"alternative-id":["10.1002\/advs.77484"],"URL":"https:\/\/doi.org\/10.1002\/advs.77484","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,13]]},"assertion":[{"value":"2026-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e77484"}}