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Cancer\u2010associated fibroblasts (CAFs) are a major component of the TME, yet their functional contributions to TNBC progression remain incompletely understood. In this study, we isolated exosomes from patient\u2010derived CAFs and normal fibroblasts (NFs), and profiled their circRNA content using RNA sequencing. circFAD104 was significantly enriched in CAFs and their derived exosomes, with elevated stromal expression confirmed by qRT\u2010PCR and in situ hybridization (ISH). PKH26 labeling demonstrated that CAF\u2010derived exosomes efficiently deliver circFAD104 to TNBC cells, where it enhances cancer stemness, metastasis, and glycolysis. Mechanistically, circFAD104 acts as a molecular scaffold to promote the interaction between the E3 ubiquitin ligase MARCHF8 and its substrate PGM1, facilitating MARCHF8\u2010mediated K48\u2010linked ubiquitination and subsequent proteasomal degradation of PGM1. Loss of PGM1 redirects glucose flux from glycogen synthesis toward glycolysis, thereby fueling tumor progression. Clinically, high circFAD104 levels were correlated with poorer overall survival in breast cancer patients. These findings uncover a CAF\u2010exosomal circFAD104 axis that reprograms glucose metabolism to drive TNBC progression via the circFAD104\/MARCHF8\/PGM1 pathway, highlighting its potential as a stroma\u2010targeted biomarker and prognostic predictor.<\/jats:p>","DOI":"10.1002\/advs.77504","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:45:58Z","timestamp":1788003958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer\u2010Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple\u2010Negative Breast Cancer via Exosomal circFAD104\u2010Mediated Intercellular Communication"],"prefix":"10.1002","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, General Surgery Qilu Hospital of Shandong University  Jinan Shandong People's Republic of 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