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Here, we present a proof\u2010of\u2010concept multifunctional capsule robot (MCR) integrating diagnostic imaging, magnetic navigation, wireless power transfer, and targeted thermotherapy. In the ex vivo environment, the MCR relies on magnetic navigation and control to position itself at the target site. This enables site\u2010specific thermal ablation, where controlled high temperatures are applied within the tissue to achieve substantial cellular destruction. These results support the feasibility of the prototype's intended functions. Through a series of in vitro cellular experiments, the MCR further demonstrated controllable temperature regulation, achieving up to 89% cell mortality under 70 heating for 120 s. The findings demonstrate the feasibility of the proposed approach at a proof\u2010of\u2010principle level. The experiments validate the system\u2010level feasibility of integrating diagnostic imaging, targeted treatment, and wireless charging within one capsule. At this stage, the platform remains a preclinical prototype and is not ready for clinical translation; further engineering and preclinical validation are required. Nonetheless, this MCR architecture provides a preliminary framework that may support future improvements in minimally invasive gastrointestinal therapeutic\u00a0systems.<\/jats:p>","DOI":"10.1002\/advs.77508","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:09:30Z","timestamp":1788757770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Preclinical Multifunctional Capsule Robot with Unified Diagnosis and Targeted Thermal Therapy for Gastrointestinal Diseases"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3673-3751","authenticated-orcid":false,"given":"Heng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering The University of Hong Kong Pokfulam Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-9702","authenticated-orcid":false,"given":"Yichong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Surgery The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0160-5808","authenticated-orcid":false,"given":"Chi\u2010Kwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering The University of Hong Kong Pokfulam Hong Kong China"},{"name":"School of Electrical and Data Engineering The University of Technology Sydney Sydney (Ultimo) New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8755-6276","authenticated-orcid":false,"given":"Yehui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2192-1864","authenticated-orcid":false,"given":"Huarong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0483-7129","authenticated-orcid":false,"given":"Paul D.","family":"Mitcheson","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Engineering Imperial College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"issue":"3","key":"e_1_2_13_2_1","first-page":"229","article-title":"Global Cancer Statistics 2022: Globocan Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray F.","year":"2024","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"6","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1586\/17434440.2014.941809","article-title":"Flexible and Capsule Endoscopy for Screening, Diagnosis and Treatment","volume":"11","author":"Sliker L. 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