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Herein, we first develop a biomimetic force\u2010electric responsive tantalum (Ta) implant with surface\u2010nanostructured LiTaO\n                    <jats:sub>3<\/jats:sub>\n                    (n\u2010 LiTaO\n                    <jats:sub>3<\/jats:sub>\n                    ) via combining laser nanofabrication and Li\n                    <jats:sup>+<\/jats:sup>\n                    \u2010induced in situ reaction, achieving favorable immunomodulation\u2010mediated vascularized osseointegration under low\u2010intensity pulsed ultrasound stimulation. The piezoelectric LiTaO\n                    <jats:sub>3<\/jats:sub>\n                    nanotentacles convert ultrasound vibration into localized electrical signals, triggering Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    influx, accelerating mitochondrial ATP production, and activating PI3K\u2013AKT signaling pathway in BMSCs to promote osteogenesis. It also orchestrates a pro\u2010osteoregenerative immune microenvironment through M2 macrophage polarization and immune\u2013osteogenic crosstalk mediated by ECM\u2013integrin\u2013FAK axis. The force\u2010electric response implant yet promotes angiogenesis mainly via enhancing intracellular Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \u2010dependent eNOS\/NO cue and cellular metabolism, reduces the inflammatory response in the dorsal subcutaneous tissue of rats, and further promotes vascularization and bone integration in femoral defects. The novel force\u2010electric response Ta implant endows real\u2010time controllable regulation of multifunctional tissue regeneration for using as patient\u2010personalized load\u2010bearing osteoarticular prostheses.\n                  <\/jats:p>","DOI":"10.1002\/advs.77514","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T02:33:31Z","timestamp":1788143611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Force\u2010Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism\/Crosstalk for Immunomodulation\u2010Vascularized Bone Integration"],"prefix":"10.1002","author":[{"given":"Taixing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Stomatology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Ji'nan Shandong Province P. R. 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