{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:12:38Z","timestamp":1788757958559,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370706"],"award-info":[{"award-number":["82370706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470799"],"award-info":[{"award-number":["82470799"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M782130"],"award-info":[{"award-number":["2025M782130"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute kidney injury (AKI) is sustained by reciprocal amplification of oxidative stress, innate immune signaling, and maladaptive immune\u2013parenchymal crosstalk. Here, we developed a lipid nanoparticle containing a ceria nanozyme and a STING\u2010targeting CasRx plasmid and functionalized it with D4F, an 18\u2010residue apolipoprotein A\u2010I mimetic peptide composed of D\u2010amino acids. The resulting D4F\u2010CeO\n                    <jats:sub>2<\/jats:sub>\n                    @LNP\u2010CasRx(STING) formulation retained radical\u2010scavenging activity, supported CasRx encapsulation, and showed enhanced cellular and renal delivery. In macrophages, the formulation reduced oxidative stress and total STING abundance together with downstream TBK1 and IRF3 phosphorylation, shifted the CD86\/CD206 profile toward a less inflammatory state, and altered the secretome in a manner that protected hypoxia\u2010challenged tubular epithelial cells. In kidney organoids and peripheral\u2010blood\u2010mononuclear\u2010cell\u2010coupled organoid cultures, D4F functionalization improved intratissue accumulation, increased the frequency of CD4\n                    <jats:sup>+<\/jats:sup>\n                    FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    T cells, and attenuated the hypoxia\u2010associated DNA damage response and tubular injury. In mice with renal ischemia\u2013reperfusion injury, treatment reduced STING signaling in CD11b\n                    <jats:sup>+<\/jats:sup>\n                    renal macrophages, improved renal function and histology, and lowered whole\u2010kidney inflammatory and injury readouts. Spatial transcriptomic and proteomic analyses were consistent with contraction of inflammatory immune states and restoration of repair\u2010associated programs. These findings support a DNA\u2010delivering nanozyme strategy for renal immune\u2010niche modulation in AKI.\n                  <\/jats:p>","DOI":"10.1002\/advs.77517","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:56:31Z","timestamp":1788756991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["D4F\u2010Functionalized Ceria Nanozyme\u2010CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9736-2658","authenticated-orcid":false,"given":"Weibo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology Cheeloo College of Medicine Qilu Hospital Shandong University  Jinan China"},{"name":"Department of Urology Cheeloo College of Medicine The Second Qilu Hospital of Shandong University Shandong University  Jinan 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