{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:07:57Z","timestamp":1788761277772,"version":"build-2803163510"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1105800"],"award-info":[{"award-number":["2022YFA1105800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["L232107"],"award-info":[{"award-number":["L232107"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    As critical interface organs, the gut and skin share substantial immunological similarities, and gut diseases are often accompanied by skin comorbidities, yet the underlying mechanisms remain unclear. Here, we observed delayed skin wound healing in a mouse model of colitis. To promote both skin and intestinal repair, we designed aryl hydrocarbon receptor (AHR)\u2013responsive carbon dots using pharmacophore modeling and fragment\u2010based drug design. These nanoscale carbon dots significantly alleviated colitis and accelerated impaired skin wound healing. The carbon dots preferentially accumulated in the inflamed colon, where they induced infiltration of tissue\u2010resident regulatory T (Treg) cells, thereby suppressing mucosal inflammation and promoting tissue repair. Mechanistically, the carbon dots activated AHR signaling to drive Treg cell differentiation. Importantly, Treg\u2010derived chemokine CCL1 enhanced macrophage efferocytosis, establishing a pro\u2010regenerative immune microenvironment in both the colon and skin wounds via STAT3\u2013SCARB1 signaling. Notably,\n                    <jats:italic>Ccl1<\/jats:italic>\n                    knockdown attenuated the therapeutic effects of carbon dots on both colonic mucosal repair and skin wound healing, supporting CCL1 as a key mediator of gut\u2013skin immune communication. Collectively, this study highlights the important role of Treg cells in gut\u2013skin axis crosstalk and provides a nanomaterial\u2010based strategy for coordinated tissue repair.\n                  <\/jats:p>","DOI":"10.1002\/advs.77526","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:24:12Z","timestamp":1788758652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["AHR\u2010Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg\u2010Mediated Macrophage Efferocytosis"],"prefix":"10.1002","author":[{"given":"Zilu","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Orthodontics National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology &amp; NMPA Key Laboratory for Dental Materials Beijing Peking University School and Hospital of Stomatology  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology &amp; NMPA Key Laboratory for Dental Materials Beijing Peking University School and Hospital of Stomatology  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Orthodontics National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology &amp; NMPA Key Laboratory for Dental Materials Beijing Peking University School and Hospital of Stomatology  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling Hospital of Stomatology Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-1037","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Restorative Dental Sciences Faculty of Dentistry The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4863-112X","authenticated-orcid":false,"given":"Xiaowei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Hospital of Jilin University Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3283-9893","authenticated-orcid":false,"given":"Ruili","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology &amp; NHC Key Laboratory of Digital Stomatology &amp; NMPA Key Laboratory for Dental Materials Beijing Peking University School and Hospital of Stomatology  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