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Herein, we report the design and fabrication of a bioinspired, multifunctional 3D nanofiber sponge (TB@CuPNS) armored with a copper\u2010chelated polydopamine (PDA) coating and functionalized with thrombin (TB). Structurally, the porous sponge demonstrated excellent mechanical resilience, strong exudate absorption capacity, and rapid hemostatic efficiency, as validated in rat liver and femoral artery hemorrhage models. Functionally, the PDA coating imparts mild NIR\u2010responsive photothermal properties (approximately 45\u00b0C) to the sponge, which worked synergistically with pH\u2010 and ROS\u2010responsive copper ion release to deliver broad\u2010spectrum antibacterial and antibiofilm effects through photothermal therapy (PTT) and chemodynamic therapy (CDT). Furthermore, copper ions and the PDA coating cooperatively scavenged excess reactive oxygen species (ROS) and modulated macrophage polarization from an M1 to an M2 phenotype. In an\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010infected diabetic mouse wound model, TB@CuPNS under NIR irradiation significantly accelerated wound repair by stimulating angiogenesis, increasing collagen deposition, and alleviating chronic inflammation. This study provides an effective strategy for fabricating advanced biomaterials that actively regulate the complex biological cascades involved in wound repair.\n                  <\/jats:p>","DOI":"10.1002\/advs.77534","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:15:41Z","timestamp":1788930941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Metal\u2010Polyphenol Self\u2010Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate\u2010Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2839-8776","authenticated-orcid":false,"given":"Ziwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Trauma Peking University People's Hospital  Beijing China"},{"name":"Key Laboratory of Trauma and Neural Regeneration 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