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Here, we constructed engineered Escherichia coli Nissle 1917 with a tannic acid\u2010mediated boronophenylalanine coating and a radiation\u2010responsive genetic circuit, enabling TME\u2010responsive boron delivery for boron neutron capture therapy (BNCT). BNCT\u2010mediated selective tumor killing spared intratumoral probiotics, whose integrated genetic circuit was triggered by the low\u2010level incidental radiation generated during the BNCT process, including \u03b3\u2010rays, to drive CXCL10 production, forming a feedback loop to remodel the TME. This strategy achieved robust tumor eradication, inhibited distal tumor growth and post\u2010surgical metastasis in murine models, pioneering a BNCT\u2010based radioimmunotherapy modality.<\/jats:p>","DOI":"10.1002\/advs.77542","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:45:48Z","timestamp":1788324348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Radiation\u2010Triggered Chemokine\u2010Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-8191","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Energy Hefei Comprehensive National Science Center\uff08Anhui Energy Laboratory\uff09 Hefei Anhui China"},{"name":"Anhui University of Science and Technology  Huainan 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