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These high aspect ratio devices are usually fabricated by complex, costly, multi\u2010step processes that limit their size and production throughput. These steps commonly involve UV or X\u2010ray lithography, semiconductor selective etching, and high\u2010Z metal plating, usually Au, which require expensive tools and materials. Here we present a proof\u2010of\u2010concept fabrication via soft lithography and Hg infusion of microfluidic X\u2010ray absorption gratings and their performance in biomedical imaging. In this work, we demonstrate gratings with a thickness of 21 , made of 10 \u2010wide lamellae and 59 \u2010wide Hg\u2010filled channels. While these initial parameters were chosen to validate the infusion process, significantly higher aspect ratios are attainable using similar, established microfluidic fabrication techniques. Such fabrication technique requires fewer, less expensive, and more scalable processes using alternative and more sustainable materials, while showing comparable visibility with their conventional Au\u2010based, solid equivalent. Our results constitute a promising shift in X\u2010ray optics fabrication that could significantly lower barriers to commercialization and accelerate the practical deployment of X\u2010ray Phase Contrast\u00a0Imaging.<\/jats:p>","DOI":"10.1002\/advs.77561","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:26:13Z","timestamp":1788931573000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microfluidic Gratings for X\u2010Ray Phase Contrast Imaging"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5642-4215","authenticated-orcid":false,"given":"Alessandro","family":"Rossi","sequence":"first","affiliation":[{"name":"Photonic Innovations Lab, Department of Electronic &amp; Electrical Engineering University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-6729","authenticated-orcid":false,"given":"Antonio","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche \u2010 Istituto di Nanotecnologia CNR\u2010NANOTEC Rende Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Coccimiglio","sequence":"additional","affiliation":[{"name":"Department of Physics and STAR Research Infrastructure University of Calabria Rende Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5036-2518","authenticated-orcid":false,"given":"Tiziana","family":"Ritacco","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche \u2010 Istituto di Microelettronica e Microsistemi Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Astolfo","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5018-0834","authenticated-orcid":false,"given":"Michele","family":"Giocondo","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche \u2010 Istituto di Nanotecnologia CNR\u2010NANOTEC Rende Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Formoso","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche \u2010 Istituto di Nanotecnologia CNR\u2010NANOTEC Rende Italy"},{"name":"Department of Physics and STAR Research Infrastructure University of Calabria Rende Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-1866","authenticated-orcid":false,"given":"Raffaele Giuseppe","family":"Agostino","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Ricerche \u2010 Istituto di Nanotecnologia CNR\u2010NANOTEC Rende Italy"},{"name":"Department of Physics and STAR Research Infrastructure University of Calabria Rende Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3564-2380","authenticated-orcid":false,"given":"Francesco","family":"Iacoviello","sequence":"additional","affiliation":[{"name":"University College London, Electrochemical Innovation Lab Department of Chemical Engineering London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1087-7020","authenticated-orcid":false,"given":"Ioannis","family":"Papakonstantinou","sequence":"additional","affiliation":[{"name":"Photonic Innovations Lab, Department of Electronic &amp; Electrical Engineering University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7150-2951","authenticated-orcid":false,"given":"Alessandro","family":"Olivo","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"59","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1126\/science.3.59.227","article-title":"On a New Kind of Rays","volume":"3","author":"Rontgen W. 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