{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:12:41Z","timestamp":1788757961377,"version":"build-2803163510"},"reference-count":71,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The persistent evolution of SARS\u2010CoV\u20102 and the concomitant risk of life\u2010threatening hyperinflammation, such as cytokine storm syndrome, underscore the urgent need for therapeutic strategies that simultaneously target viral replication and dysregulated host immunity. Herein, we describe a dual\u2010membrane biomimetic nanoplatform, designated [A&amp;T]MLN, comprising siRNA\u2010loaded lipid nanoparticles with a hybrid membrane derived from ACE2\u2010overexpressing HEK293T cells and THP\u20101 macrophages. This design integrates a high\u2010density viral decoy based on ACE2 with the inherent immunomodulatory capacity of macrophage membranes. [A&amp;T]MLN demonstrates broad\u2010spectrum and potent neutralization of diverse SARS\u2010CoV\u20102 variants by competitively blocking viral entry, while actively scavenging key inflammatory cytokines (including IL\u20106, IL\u20101\u03b2, and TNF\u2010\u03b1) via membrane\u2010displayed receptors. In a murine model of acute lung injury that recapitulates COVID\u201019 immunopathology, [A&amp;T]MLN treatment significantly attenuated pulmonary inflammation and tissue damage. Additionally, the platform enabled efficient cytosolic delivery of siRNA, establishing a third modality for intracellular suppression of viral gene expression. Collectively, [A&amp;T]MLN represents a complementary triple\u2010modal therapy that simultaneously addresses viral entry, intracellular replication, and hyperinflammation (the core interconnected pathologies of severe COVID\u201019), offering a versatile and adaptive strategy against evolving SARS\u2010CoV\u20102 variants and related inflammatory syndromes.<\/jats:p>","DOI":"10.1002\/advs.77581","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:59:01Z","timestamp":1788757141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Dual\u2010Membrane Biomimetic Nanoplatform Enables Triple\u2010Modal Therapy Against SARS\u2010CoV\u20102 Through Viral Decoy, Inflammation Neutralizing, and Intracellular 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