{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:06:16Z","timestamp":1788933976118,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271286"],"award-info":[{"award-number":["82271286"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302417"],"award-info":[{"award-number":["82302417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sepsis\u2010associated encephalopathy (SAE) is a severe neurological complication of sepsis, yet how metabolic disturbances engage epigenetic regulation in SAE remains unclear. We found that septic mice exhibited hippocampal succinate and succinyl\u2010CoA accumulation, accompanied by enhanced neuronal histone H2BK120 succinylation (H2BK120su). Pharmacological reduction of succinylation alleviated neuronal injury and improved cognitive function. Mechanistically, integrated CUT&amp;Tag and transcriptomic analyses identified\n                    <jats:italic>Pdcd1<\/jats:italic>\n                    as a downstream gene associated with H2BK120su enrichment. H2BK120su enrichment at the\n                    <jats:italic>Pdcd1<\/jats:italic>\n                    promoter activated the PD\u20101\/PD\u2010L1 axis, promoted mitochondrial translocation of PD\u2010L1 and its interaction with PINK1, and triggered PINK1\/Parkin\u2010dependent mitophagy, leading to mitochondrial dysfunction and neuronal apoptosis. Neutralization of PD\u20101\/PD\u2010L1 or knockdown of\n                    <jats:italic>Pdcd1<\/jats:italic>\n                    attenuated mitophagy and neuronal injury. We further identified SIRT7 downregulation as a major cause of H2BK120su accumulation in the septic hippocampus. Neuron\u2010specific\n                    <jats:italic>Sirt7<\/jats:italic>\n                    deletion exacerbated H2BK120su enrichment, PD\u20101\/PD\u2010L1 activation, excessive mitophagy, and cognitive impairment, whereas SIRT7 overexpression reversed these pathological changes. Together, our findings define a SIRT7\u2010H2BK120su\u2010PD\u20101\/PD\u2010L1\u2010PINK1 axis linking metabolic reprogramming to aberrant mitophagy in SAE and suggest SIRT7\u2010dependent succinylation as a potential therapeutic target.\n                  <\/jats:p>","DOI":"10.1002\/advs.77642","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:06:56Z","timestamp":1788930416000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SIRT7\u2010Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis\u2010Associated Cognitive Dysfunction"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2859-7040","authenticated-orcid":false,"given":"Na","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Huadong Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiateng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Shanghai Tongji Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Huadong Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Huadong Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9718-6020","authenticated-orcid":false,"given":"Xuelian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai General Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai General Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai General Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xixue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Huadong Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Huadong Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai General Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangfang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai General Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shanghai General Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-5839","authenticated-orcid":false,"given":"Weidong","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Huadong Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1007\/s12035-021-02303-2","article-title":"Nunes FB. 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