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Organic mixed ionic\u2013electronic conductors provide a materials platform that supports concurrent ionic and electronic transport within the same bulk medium, enabling conductance to evolve continuously under electrochemical stimuli. This review examines organic electrochemical transistors as a unifying device architecture in which electrochemical gating induces volumetric (de)doping, coupling channel geometry and electrolyte accessibility to ionic time constants, nonlinearity, retention or volatility, and energy dissipation. Materials coverage includes conducting polymers such as poly(3,4\u2010ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS), glycolated conjugated semiconductors, donor\u2013acceptor mixed conductors enabling n\u2010type and complementary operation, and semiconducting hydrogels and composites engineered for aqueous stability and tissue\u2010like mechanical compliance. Manufacturing strategies ranging from microfabrication and lithographic patterning to printing\u2010based additive manufacturing (AM) and hybrid process flows are discussed, with emphasis on their roles in defining planar and vertical device architectures and electrolyte integration. Neuromorphic functionalities are analyzed across hierarchical levels, spanning synaptic primitives including excitatory postsynaptic current, short\u2010term plasticity, long\u2010term plasticity, and spike\u2010timing\u2010dependent plasticity, as well as artificial neurons, reservoir computing, and closed\u2010loop biohybrid sensing\u2013processing interfaces.<\/jats:p>","DOI":"10.1002\/advs.77655","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:40:14Z","timestamp":1789623614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5860-1963","authenticated-orcid":false,"given":"Hyunjin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering The Pennsylvania 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