{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:54:25Z","timestamp":1790790865871,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["181290"],"award-info":[{"award-number":["181290"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["220977"],"award-info":[{"award-number":["220977"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality worldwide and a major contributor to global morbidity. Although several interventions exist in high\u2010income countries, current solutions often suffer from poor field\u2010compatibility, limited efficacy, complex application, insufficient hemostatic support, and difficult removal. Here, a hemostatic foam designed for field compatibility and made from stable precursors, together with an easy\u2010to\u2010use delivery device for treating life\u2010threatening PPH is introduced. The device enables rapid, user\u2010friendly generation and intrauterine application of a hydrogel foam, which controls bleeding through both coagulation support and tamponade pressure before safely degrading. The expanding foam achieves the target pressure range of standard intrauterine tamponade (67\u201392\u00a0mmHg), confirmed across in vitro, ex vivo, and in vivo models. Induced degradation produces 76 \u00b1 8% mass loss within 6\u00a0h, with storage modulus dropping from 2.98 \u00b1 0.08\u00a0kPa after fabrication to 1.60 \u00b1 0.25\u00a0kPa after partial degradation. Incorporation and controlled release of tranexamic acid and cefuroxime show versatility in topical drug delivery. Beyond extensive ex vivo testing, rapid, controlled deployment in vivo in a swine model is demonstrated. By integrating mechanical and chemical mechanisms, this injectable foam provides effective bleeding control, with a design well suited to low\u2010resource settings.<\/jats:p>","DOI":"10.1002\/advs.77669","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:00:31Z","timestamp":1790532031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Injectable, Self\u2010Expanding Hemostatic Foam for Field\u2010Compatible Postpartum Hemorrhage Management"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5599-9127","authenticated-orcid":false,"given":"Charlotte","family":"Meyer","sequence":"first","affiliation":[{"name":"The Ingenuity Lab Balgrist University Hospital  Zurich Switzerland"},{"name":"Department of Mechanical and Process Engineering (D\u2010MAVT) Nanoparticle Systems Engineering Laboratory Institute of Energy and Process Engineering (IEPE) ETH Zurich  Zurich Switzerland"},{"name":"Department of Materials Meet Life Nanomaterials in Health Laboratory Swiss Federal Laboratories For Materials Science and Technology (Empa)  St Gallen Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9187-4671","authenticated-orcid":false,"given":"No\u00ebl","family":"Strasser","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Process Engineering (D\u2010MAVT) Nanoparticle Systems Engineering Laboratory Institute of Energy and Process Engineering (IEPE) ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilakkiya","family":"Ravindrarajah","sequence":"additional","affiliation":[{"name":"The Ingenuity Lab Balgrist University Hospital  Zurich Switzerland"},{"name":"Department of Mechanical and Process Engineering (D\u2010MAVT) Nanoparticle Systems Engineering Laboratory Institute of Energy and Process Engineering (IEPE) ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9953-4463","authenticated-orcid":false,"given":"Elsa","family":"Wrenger","sequence":"additional","affiliation":[{"name":"The Ingenuity Lab Balgrist University Hospital  Zurich Switzerland"},{"name":"Department of Mechanical and Process Engineering (D\u2010MAVT) Nanoparticle Systems Engineering Laboratory Institute of Energy and Process Engineering (IEPE) ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Ivkovic","sequence":"additional","affiliation":[{"name":"The Ingenuity Lab Balgrist University Hospital  Zurich Switzerland"},{"name":"Department of Mechanical and Process Engineering (D\u2010MAVT) Nanoparticle Systems Engineering Laboratory Institute of Energy and Process Engineering (IEPE) ETH Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0557-5538","authenticated-orcid":false,"given":"Jan","family":"\u0160ev\u010d\u00edk","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine in Pilsen Charles University  Prague Czech Republic"},{"name":"Biomedical Center Faculty of Medicine in Pilsen Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3318-3053","authenticated-orcid":false,"given":"Sima","family":"\u0160ar\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine in Pilsen Charles University  Prague Czech Republic"},{"name":"Biomedical Center Faculty of Medicine in Pilsen Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-210X","authenticated-orcid":false,"given":"Lenka","family":"\u010cervenkov\u00e1","sequence":"additional","affiliation":[{"name":"Biomedical Center Faculty of Medicine in Pilsen Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2125-0685","authenticated-orcid":false,"given":"J\u00e1chym","family":"Rosendorf","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine in Pilsen Charles University  Prague Czech Republic"},{"name":"Biomedical Center Faculty of Medicine in Pilsen Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e1clav","family":"Li\u0161ka","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine in Pilsen Charles University  Prague Czech Republic"},{"name":"Biomedical Center Faculty of Medicine in Pilsen Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre H.","family":"Anthis","sequence":"additional","affiliation":[{"name":"The Ingenuity Lab Balgrist University Hospital  Zurich Switzerland"},{"name":"Department of Mechanical and Process Engineering (D\u2010MAVT) Nanoparticle Systems Engineering Laboratory Institute of Energy and Process Engineering (IEPE) ETH Zurich  Zurich Switzerland"},{"name":"Department of Materials Meet Life Nanomaterials in Health Laboratory Swiss Federal Laboratories For Materials Science and Technology (Empa)  St Gallen Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-5002","authenticated-orcid":false,"given":"Thomas","family":"Rduch","sequence":"additional","affiliation":[{"name":"Department of Materials Meet Life Nanomaterials in Health Laboratory Swiss Federal Laboratories For Materials Science and Technology (Empa)  St Gallen Switzerland"},{"name":"Department of Gynecology Cantonal Hospital St Gallen (KSSG)  St Gallen Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-6796","authenticated-orcid":false,"given":"Inge K.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"The Ingenuity Lab Balgrist University Hospital  Zurich Switzerland"},{"name":"Department of Mechanical and Process Engineering (D\u2010MAVT) Nanoparticle Systems Engineering Laboratory Institute of Energy and Process Engineering (IEPE) ETH Zurich  Zurich Switzerland"},{"name":"Department of Materials Meet Life Nanomaterials in Health Laboratory Swiss Federal Laboratories For Materials Science and Technology (Empa)  St Gallen Switzerland"},{"name":"Faculty of Medicine University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization \u201cA Roadmap to Combat Postpartum Haemorrhage Between 2023 and 2030 \u201d (Geneva Switzerland: World Health Organization 2023) Licence: CC BY\u2010NC\u2010SA 3.0 IGO."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-276"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000507"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.47363\/JCCEM\/2023(2)134"},{"key":"e_1_2_9_7_1","article-title":"Uterotonic Agents for First\u2010line Treatment of Postpartum Haemorrhage: A Network Meta\u2010Analysis","volume":"11","author":"Smith W. R. P.","year":"2020","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.08.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13692"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.12788\/obgm.0302"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13596"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.06.003"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"World Health Organization \u201cConsolidated Guidelines for the Prevention Diagnosis and Treatment of Postpartum Haemorrhage: web annexes: evidence base \u201d (Geneva Switzerland: World Health Organization 2023) Licence: CC BY\u2010NC\u2010SA 3.0 IGO https:\/\/doi.org\/10.2471\/B09571.","DOI":"10.2471\/B09571"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-025-07236-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED-D-09-00185"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.132559"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.75329"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202419037"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c20450"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6c05034"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1962288"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004135"},{"key":"e_1_2_9_23_1","unstructured":"U.Sharma et\u00a0al. \u201cFoam and Delivery System for Treatment of Postpartum Hemorrhage \u201d US20130110066A1 (2013)."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000003091"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000126"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102364"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b00453"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.79639"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-7037(00)00510-X"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308701"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127960"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.4c01105"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121673"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35849-8"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.06.001"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.9.3.511"},{"key":"e_1_2_9_37_1","unstructured":"World Health Organization \u201cUpdated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage \u201d (Geneva Switzerland: World Health Organization 2017) Licence: CC BY\u2010NC\u2010SA 3.0 IGO. WHO\/RHR\/17.21."},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/195036"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.10.040"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2024.2425159"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000006295"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.05.004"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.289"},{"key":"e_1_2_9_44_1","article-title":"Utility of Saline Infusion Sonohysterography in Gynecology: A Review Article","volume":"15","author":"Kumar K.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.01.062"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2026.115267"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/07399332.2021.1998059"},{"key":"e_1_2_9_48_1","first-page":"11524","article-title":"Intraluminal Pressure Difference of Bakri Balloon in the Positive Tamponade Test during the Management of Severe Post\u2010Partum Hemorrhage","volume":"15","author":"Li H.","year":"2019","journal-title":"Journal of Scientific & Technical Research"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-011723-021442"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41684-024-01349-8"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.14227\/DT180311P15"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310301"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202301406"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2017.09.026"},{"key":"e_1_2_9_56_1","unstructured":"S.Tatham \u201cPuTTY: A Free SSH and Telnet Client \u201d version 0.81 accessed August2026 https:\/\/www.chiark.greenend.org.uk\/~sgtatham\/putty\/."},{"key":"e_1_2_9_57_1","unstructured":"ANSYS Workbench Release 2024 R2 (ANSYS Inc. 2024)."},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1108\/RPJ-01-2022-0032"},{"key":"e_1_2_9_59_1","unstructured":"Posit Team RStudio: Integrated Development Environment for R version 2025.05.0 Posit Software (PBC 2025)."}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77669","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.77669","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.77669","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:54:18Z","timestamp":1790787258000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.77669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":58,"alternative-id":["10.1002\/advs.77669"],"URL":"https:\/\/doi.org\/10.1002\/advs.77669","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e77669"}}