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To address these challenges, we developed a novel \u201cdrug carrier\u2010integrated\u201d oral probiotic delivery system\u2014\n                    <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                    @ZGM\u2014based on a zinc glycyrrhizinate microgel (ZGM) derived from the clinical anti\u2010inflammatory agent Licorzinc. This multifunctional gel encapsulates\n                    <jats:italic>L. reuteri<\/jats:italic>\n                    within a porous network, achieving a 23.08\u2010fold increase in survival rate under simulated gastric conditions and a 37.22\u2010fold increase in intestinal colonization in mice compared to unencapsulated bacteria. Beyond protection, ZGM actively scavenges ROS at inflammatory sites, facilitates probiotic adhesion to the mucus layer, and modulates the local microenvironment to favor colonization. In both dextran sulfate sodium (DSS)\u2010induced colitis and IL\u201010\u2010deficient spontaneous colitis mouse models,\n                    <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                    @ZGM persistently scavenged ROS, effectively reduced pro\u2010inflammatory cytokine levels, restored the expression of tight junction\u2010associated proteins and intestinal barrier function, enhanced probiotic colonization and survival, and reshaped the gut microbiota. These findings establish\n                    <jats:italic>L.\u00a0reuteri<\/jats:italic>\n                    @ZGM as a potent therapeutic strategy that integrates microenvironment modulation and probiotic delivery\u2014offering a clinically translatable approach to treating inflammatory bowel diseases.\n                  <\/jats:p>","DOI":"10.1002\/advs.77674","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T05:58:01Z","timestamp":1789365481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Zinc Glycyrrhizinate\u2010Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis"],"prefix":"10.1002","author":[{"given":"Mengyun","family":"Peng","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics School of Biomedical Sciences Hunan University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Chen","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics School of Biomedical Sciences Hunan University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics School of Biomedical Sciences Hunan University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Tang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics School of Biomedical Sciences Hunan University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics School of Biomedical Sciences Hunan University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1496-8800","authenticated-orcid":false,"given":"Xia","family":"Wu","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics School of Biomedical Sciences Hunan University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2831-0388","authenticated-orcid":false,"given":"Dan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics School of Biomedical Sciences Hunan University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Shan","sequence":"additional","affiliation":[{"name":"Changsha Stomatological Hospital  Changsha Hunan China"},{"name":"School of Stomatology Hunan University of Chinese Medicine  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7705-8866","authenticated-orcid":false,"given":"Junfeng","family":"Shi","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Animal Models and Molecular Medicine State Key Laboratory of Chemo\/Bio\u2010Sensing and Chemometrics School of Biomedical Sciences Hunan University  Changsha Hunan China"},{"name":"Shenzhen Research Institute Hunan University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/540S97a"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(19)30333\u20104"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat0835"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101237\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(94)92831\u20102"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c02646"},{"issue":"11","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1038\/s41591-021-01570-9","article-title":"CDK4\/6 inhibitors in Breast Cancer: Spotting the Difference","volume":"27","author":"Perez\u2010Garcia J. 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